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Product Image-462-0554

VWR® VWB2, Lázně vodní

Dodavatel: VWR Collection
Popis: Vodní lázně s dvojitou stěnou, vnitřní stěna z nerezové oceli a vnější z ocelových plátů s povrchovou úpravou. Všechny lázně s výjimkou 2litrového modelu mají vypouštěcí kohout a mohou být využívány s vodou nebo kovovými kuličkami. Lázně od objemu 5 l mají program pro ohřev s kuličkami, který se spouští z hlavní nabídky. Součástí volitelného příslušenství je zátka do odpadu, která chrání před případným ucpáním kuličkou, která by mohla zapadnout do odpadu. Poznámka: Lázně jsou klasifikovány jako bezpečné Safety Class 1, což znamená, že mohou běžet bez dozoru, pokud v nich nejsou používány hořlavé kapaliny.

Image Unavailable-BWRLBS7184

Anti-Ob-R Rabbit Polyclonal Antibody

Katalogové číslo: (BWRLBS7184)
Dodavatel: Bioworld Technology
Popis: Recombinant full length Human Ob-R.
Měrná jednotka: 1 * 100 µG
Image Unavailable-ABCAAB129760-100

Anti-OB Cadherin Rabbit Polyclonal Antibody

Katalogové číslo: (ABCAAB129760-100)
Dodavatel: Abcam
Popis: Anti-OB Cadherin Rabbit Polyclonal Antibody
Měrná jednotka: 1 * 100 µG
Product Image-462-0282

VWR®, Replacement Lids for VWR® Water Baths

Dodavatel: VWR Collection
Popis: Víko náhradní pro otevřené lázně, VWR®, Polykarbonátové lázně s objemem 8 litrů

Image Unavailable-BWRLBS3460

Anti-Ob-R Rabbit Polyclonal Antibody [clone: L662]

Katalogové číslo: (BWRLBS3460)
Dodavatel: Bioworld Technology
Popis: Synthetic peptide, corresponding to amino acids 650-700 of Human Ob-R.
Měrná jednotka: 1 * 100 µG
Image Unavailable-BWRLBS2684

Anti-OB-cadherin Rabbit Polyclonal Antibody [clone: K444]

Katalogové číslo: (BWRLBS2684)
Dodavatel: Bioworld Technology
Popis: Synthetic peptide, corresponding to amino acids 430-480 of Human OB-cadherin.
Měrná jednotka: 1 * 100 µG
Image Unavailable-BOSSBS-0961M-HRP

Anti-LEPR Mouse Polyclonal Antibody (HRP (Horseradish Peroxidase))

Katalogové číslo: (BOSSBS-0961M-HRP)
Dodavatel: Bioss
Popis: Leptin receptor (OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. An OB-R transcript encodes a soluble form of the receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist. Human OB-R encodes a 1 165 amino acid residue precursor protein with a 22 amino acid residue signal peptide, an 816 amino acid residue extracellular domain, a 21 amino acid residue transmembrane domain and a 303 amino acid residue cytoplasmic domain.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BWRLBS3494

Anti-Ob Rabbit Polyclonal Antibody [clone: K36]

Katalogové číslo: (BWRLBS3494)
Dodavatel: Bioworld Technology
Popis: Synthetic peptide, corresponding to amino acids N-terminus of Human Ob.
Měrná jednotka: 1 * 100 µG
Image Unavailable-CAYM71740-25

Rosiglitazone ≥98%

Dodavatel: Cayman Chemical
Popis: Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions <italic>in vivo</italic>. Rosiglitazone is a prototypical TZD and has served as a reference compound for this class. Rosiglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC<sub>50</sub> values of approximately 30 nM and 100 nM, respectively. Rosiglitazone is active <italic>in vivo</italic> as an antidiabetic agent in the <italic>ob/ob</italic> mouse model, and has been used as an oral hypoglycemic agent in the treatment of Type II diabetes in humans for many years.

Image Unavailable-CAYM10005647-10

Cerulenin ≥98%, crystalline solid

Dodavatel: Cayman Chemical
Popis: A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway. Cerulenin also leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.

Image Unavailable-BOSSBS-11536R-CY3

Anti-TUB1 Rabbit Polyclonal Antibody (Cy3®)

Katalogové číslo: (BOSSBS-11536R-CY3)
Dodavatel: Bioss
Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11536R-A488

Anti-TUB1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Katalogové číslo: (BOSSBS-11536R-A488)
Dodavatel: Bioss
Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11536R-A680

Anti-TUB 1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Katalogové číslo: (BOSSBS-11536R-A680)
Dodavatel: Bioss
Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice, mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population. In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss. The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr and Bardet-Biedl. A candidate for the tub gene has been described. A G - transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron. A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice. It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11536R

Anti-TUB1 Rabbit Polyclonal Antibody

Katalogové číslo: (BOSSBS-11536R)
Dodavatel: Bioss
Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11536R-A647

Anti-TUB1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Katalogové číslo: (BOSSBS-11536R-A647)
Dodavatel: Bioss
Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-11536R-A350

Anti-TUB1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Katalogové číslo: (BOSSBS-11536R-A350)
Dodavatel: Bioss
Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
Měrná jednotka: 1 * 100 µl
Cena na vyžádání
Omezené množství produktu na skladě. Zboží může být k dispozici v jiném skladě poblíž vašeho sídla. Přesvědčte se, že jste přihlášení na stránky, abyste mohli vidět dostupné položky na skladě. Pokud je stále zobrazeno call a potřebujete asistenci, volejte na číslo 321 570 321.
Omezené množství produktu na skladě. Zboží může být k dispozici v jiném skladě poblíž vašeho sídla. Přesvědčte se, že jste přihlášení na stránky, abyste mohli vidět dostupné položky na skladě. Pokud je stále zobrazeno call a potřebujete asistenci, volejte na číslo 321 570 321.
Daná chemikálie je regulována dle platné legislativy a bude vyžadováno vyplnění formuláře. Jeho včasným vyplněním uspíšíte dodání produktu.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Tento produkt je zablokován vaší organizací. Kontaktujte své nákupní oddělení pro více informací.
Původní produkt již není k dispozici. Zobrazen je náhradní produkt.
Tento produkt již není k dispozici. Podobné produkty můžete vyhledat pomocí VWR katalogových čísel nebo čísel dodavatele uvedených výše. Pokud potřebujete další asistenci, zavolejte na telefonní číslo zákaznického servisu VWR 321 570 321.
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