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Popis: Human recombinant UBE2K (from <i>E. coli</i>)

Katalogové číslo: BIRBORB49718-10

Měrná jednotka: 1 * 10 µG

Dodavatel: Biorbyt

Akce

Popis: Anti-UBR2 Rabbit Polyclonal Antibody

Katalogové číslo: ABNOH00023304-D01

Měrná jednotka: 1 * 100 µl

Dodavatel: Abnova

Akce

Popis: Goat polyclonal antibody raised against synthetic peptide of UBE2F.

Katalogové číslo: ABNOPAB6307

Měrná jednotka: 1 * 100 µG

Dodavatel: Abnova

Akce

Popis: Goat polyclonal antibody raised against synthetic peptide of UBE2T.

Katalogové číslo: ABNOPAB6306

Měrná jednotka: 1 * 100 µG

Dodavatel: Abnova

Akce

Popis: Anti-UBE2T Mouse Polyclonal Antibody

Katalogové číslo: ABNOH00029089-B01

Měrná jednotka: 1 * 50 µl

Dodavatel: Abnova

Akce

Popis: Anti-UBE2F Goat Polyclonal Antibody

Katalogové číslo: PRSI42-142

Měrná jednotka: 1 * 100 µG

Dodavatel: ProSci Inc.

Akce

Popis: Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins.

Katalogové číslo: PRSI91-166

Měrná jednotka: 1 * 50 µG

Dodavatel: ProSci Inc.

Akce

Popis: UBE2K belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.

Katalogové číslo: PRSI27-124

Měrná jednotka: 1 * 50 µG

Dodavatel: ProSci Inc.

Akce

Popis: Anti-UBE2Z Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalogové číslo: USBI043538-FITC

Měrná jednotka: 1 * 200 µl

Dodavatel: US Biological

Akce

Popis: Anti-UBE2K Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))

Katalogové číslo: USBI043523-AP

Měrná jednotka: 1 * 200 µl

Dodavatel: US Biological

Akce

Popis: Anti-UBE2T Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Katalogové číslo: USBI043534-FITC

Měrná jednotka: 1 * 200 µl

Dodavatel: US Biological

Akce

Popis: Anti-UBN2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Katalogové číslo: USBI043548-HRP

Měrná jednotka: 1 * 200 µl

Dodavatel: US Biological

Akce

Popis: Anti-UBE2N Mouse Monoclonal Antibody [clone: 3G1-D10]

Katalogové číslo: USBI135009

Měrná jednotka: 1 * 100 µG

Dodavatel: US Biological

Akce

Popis: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2C, also designated UBCH10 in human, is an E2 ubiquitin conjugating enzyme for the anaphase promoting complex (APC), which coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle regulators. UBE2C is overexpressed in many different types of cancers and may be a potential therapeutic target.

Katalogové číslo: BOSSBS-8357R-A680

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.

Katalogové číslo: BOSSBS-8382R-A488

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). UBC13, also known as UBE2N or BLU, is a 152 amino acid member of the E2 ubiquitin-conjugating enzyme family. Existing as a heterodimer with Mms2 (also known as UBE2V2), UBC13 catalyzes the ATP-dependent synthesis of non-canonical polyubiquitin chains, a process that does not lead to proteasomal degradation. Additionally, UBC13 mediates the transcription of several target genes and is thought to play a role in cell cycle progression, cellular differentiation and DNA repair mechanisms that ensure cell survival after DNA damage.

Katalogové číslo: BOSSBS-8351R-A647

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce