Hledali jste: Palladium(II)+sulphate+dihydrate

Popis: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumour suppressor. May also play a minor role in oogenesis (By similarity).

Katalogové číslo: BOSSBS-11276R-A680

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: MSY2 and YB-2 (MSY3,4) belong to the Y-box family of multifunctional proteins that regulate both transcription and translation (1–3). Y-box proteins interact with a wide variety of nucleic acid structures to act as transcription factors and mRNA masking proteins (1). The modular structure of Y-box proteins includes a highly conserved N-terminal cold-shock domain (CSD, equivalent to the bacterial cold-shock proteins) and four basic C-terminal domains containing arginine clusters and aromatic residues (4). MSY2 is expressed in testis and ovary where it may repress translation of parental mRNA (5,6). The gene encoding human MSY2 maps to chromosome 17p11.2-13.1 (5). YB-2 (MSY3,4 in mouse) is also known as DNA binding protein A and is highly expressed in the testis, heart and muscle (7,8). MSY2 and YB-2 bind to the consensus sequence 5'-UCCAUCA-3' contained in the Y-box element (9).

Katalogové číslo: BOSSBS-12271R-CY3

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF141 (ring finger protein 141), also known as ZFP26 or ZNF230, is a 230 amino acid protein that contains one RING-type zinc finger. Expressed as two isoforms (isoform 1 and isoform 2) due to alternative splicing events, RNF141 is thought to function as a transcription factor during spermatogenesis. While isoform 2 is expressed in brain, heart, pancreas, kidney and skeletal muscle, isoform 1 is expressed primarily in testis, suggesting that isoform 1 functions during spermatogenesis. In addition, RNF141 is not expressed in azoospermic (infertile) men, further implicating an important role for RNF141 in testis development and male fertility.

Katalogové číslo: BOSSBS-9143R-FITC

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF141 (ring finger protein 141), also known as ZFP26 or ZNF230, is a 230 amino acid protein that contains one RING-type zinc finger. Expressed as two isoforms (isoform 1 and isoform 2) due to alternative splicing events, RNF141 is thought to function as a transcription factor during spermatogenesis. While isoform 2 is expressed in brain, heart, pancreas, kidney and skeletal muscle, isoform 1 is expressed primarily in testis, suggesting that isoform 1 functions during spermatogenesis. In addition, RNF141 is not expressed in azoospermic (infertile) men, further implicating an important role for RNF141 in testis development and male fertility.

Katalogové číslo: BOSSBS-9143R-CY5

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. [provided by RefSeq, Jan 2012]

Katalogové číslo: BOSSBS-4501R-HRP

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: OXCT2 is a testis-specific succinyl-CoA:3-oxoacid CoA transferase (EC 2,8,3,5), which catalyses the reversible transfer of CoA from succinyl-CoA to acetoacetate in the first step of ketone body utilisation. See also OXCT1 (MIM 601424).

Katalogové číslo: BOSSBS-15589R-CY3

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: OXCT2 is a testis-specific succinyl-CoA:3-oxoacid CoA transferase (EC 2,8,3,5), which catalyses the reversible transfer of CoA from succinyl-CoA to acetoacetate in the first step of ketone body utilisation. See also OXCT1 (MIM 601424).

Katalogové číslo: BOSSBS-15589R-FITC

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: MFAP3L is a membrane protein that is highly expressed in testis. It contains 1 Ig-like C2-type (immunoglobulin-like) domain and has three named isoforms produced by alternative splicing. Its function remains unknown.

Katalogové číslo: BOSSBS-5101R-A488

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: MFAP3L is a membrane protein that is highly expressed in testis. It contains 1 Ig-like C2-type (immunoglobulin-like) domain and has three named isoforms produced by alternative splicing. Its function remains unknown.

Katalogové číslo: BOSSBS-5101R-A647

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: MFAP3L is a membrane protein that is highly expressed in testis. It contains 1 Ig-like C2-type (immunoglobulin-like) domain and has three named isoforms produced by alternative splicing. Its function remains unknown.

Katalogové číslo: BOSSBS-5101R-HRP

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Involved in the conversion of lanosterol to cholesterol.Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes.

Katalogové číslo: BOSSBS-4221R-A680

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner.Tissue specificity: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.

Katalogové číslo: BOSSBS-7745R-A555

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: XAGE2 belongs to the GAGE family of genes which are expressed in a variety of tumors and in some fetal and reproductive tissues. XAGE2 is strongly expressed in normal testis, and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. Its function is unknown.

Katalogové číslo: BOSSBS-7017R-FITC

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.Tissue specificity: Ubiquitous. Highest in testis.

Katalogové číslo: BOSSBS-7912R-A647

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: TULP2 is a member of a family of tubby-like (TULP) proteins which share a conserved C terminal region of approximately 200 amino acid residues. It is strongly expressed in testis and is expressed in the retina. It is also expressed in cancer cell lines.

Katalogové číslo: BOSSBS-6746R-HRP

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce

Popis: Involved in the conversion of lanosterol to cholesterol.Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes.

Katalogové číslo: BOSSBS-4221R-A488

Měrná jednotka: 1 * 100 µl

Dodavatel: Bioss

Akce