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Anti-PDIA2 Rabbit Polyclonal Antibody (Cy5.5®)

Katalogové číslo: (BOSSBS-4250R-CY5.5)

Dodavatel: Bioss

Popis: The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

Měrná jednotka: 1 * 100 µl

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Tungsten (gold coated) ≥99.95% (metals basis) Au 99.99%, wire, Ø 0.025 mm (0.001 in)

Dodavatel: Thermo Fisher Scientific

Popis: Tungsten (gold coated) ≥99.95% (metals basis) Au 99.99%, wire, Ø 0.025 mm (0.001 in)

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Dimethyldisulfid ≥99%

Dodavatel: Thermo Fisher Scientific

Popis: Dimethyldisulfid ≥99%

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Tungsten(IV) carbide ≥99.5% (metals basis)

Dodavatel: Thermo Fisher Scientific

Popis: Tungsten(IV) carbide ≥99.5% (metals basis)

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sirouhlík ≥99.9% (by GC, corrected for water content), BAKER ANALYZED® ACS, J.T.Baker®

Dodavatel: Avantor

Popis: The quality of many BAKER ANALYZED™ Reagents meets or exceeds the requirements set forth by the American Chemical Society (ACS). These solvents are essential for any chemical stockroom.

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