Hledali jste: Bis(methylthio)gliotoxin

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Bis(methylthio)gliotoxin ≥99% (by TLC)

Dodavatel: ENZO LIFE SCIENCES

Popis: Inhibits PAF-induced platelet aggregation (IC50=8.4 µM) and collagen-induced aggregation (IC50=84.2 µM) with no effect on arachidonic acid or ADP induced aggregation. Inhibits PAF-induced bronchoconstriction in vivo in the guinea-pig (69% at 1.0 mg/kg).

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Gliotoxin (from Gladiocladium fimbriatum) ≥97% (by HPLC, TLC)

Dodavatel: ENZO LIFE SCIENCES

Popis: Immunomodulating mycotoxin which acts by blocking membrane thiol groups. Inhibits the chymotrypsin-like activity of the 20S proteasome in a non-competitive manner. Causes apoptotic cell death in macrophages and thymocytes. Induces Ca2+ release from intact rat liver mitochondria. Inhibits the activation of transcription factor NF-κB in response to a variety of stimuli in T and B cells. Displays anti-inflammatory activity in vivo. Antioxidant. Inhibitor of farnesyltransferase and geranylgeranyltransferase I. A negative control analog is available. Displays anti-tumor activity against breast cancer in vivo.

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