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4,4-Difluoro-1-(2-furyl)butane-1,3-dione

Dodavatel: Apollo Scientific

Popis: 4,4-Difluoro-1-(2-furyl)butane-1,3-dione

2-(2-Mercaptoethyl)isoindoline-1,3-dione 95+%

Dodavatel: Apollo Scientific

Popis: 2-(2-Mercaptoethyl)isoindoline-1,3-dione 95+%

6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione 95%

Katalogové číslo: (APOSOR33547-1G)

Dodavatel: Apollo Scientific

Popis: 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione 95%

Měrná jednotka: 1 * 1 g

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WYE-125132 ≥98%, crystalline solid

Dodavatel: Cayman Chemical

Popis: WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.