Hledali jste: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanoi

Katalogové číslo: (ENZOALX350013M025)

Dodavatel: ENZO LIFE SCIENCES

Popis: Olomoucine is a purine derivative which acts as a potent and selective inhibitor of CDK1 (p34cdc2)/cyclin B and related kinases. It acts by competing for the ATP binding domain of the kinase. Of 35 protein kinases tested, olomoucine inhibited p33CDK2/cyclin A, p33CDK2/cyclin E, p34cdc2/cyclin B, p33CDK5/p35 and erk1 with IC50 of 7, 7, 7, 3 and 25µM respectively. The related kinases p34CDK4/cyclin D and p40CDK6/cyclin D3 were not inhibited or were less sensitive to olomoucine, IC50 > 1000 and 250µM respectively. PKC, PKA, PKG, CaM kinase II, MLC kinase, CK2, EGFR tyrosine kinase, p56lck, p56lyn, p60c-src, v-abl and insulin receptor tyrosine kinase are not inhibited or are weakly inhibited at 1mM. It delays mouse oocyte maturation and inhibits the growth of a variety of human cell lines including Rhabdomyosarcoma cell line Rh1, Rh18, Rh28 and Rh30; MCF-7, KB-3-1 and their adriamycin-resistant counterparts (IC50=18-86µM). It inhibits DNA synthesis in interleukin-2-stimulated T lymphocytes and triggers a G1 arrest similar to interleukin-2 deprivation. Can be used to synchronize cells in G1. Triggers apoptosis in target tumor cells in vitro and in vivo and in maturing cerebellar granule neurons. N9-Isopropyl-olomoucine and the negative control Iso-olomoucine are also available.

Měrná jednotka: 1 * 25 mg

New Product Akce

Dodavatel: Apollo Scientific

Popis: 3-[(Methoxymethylamino)carbonyl]-1-azetidinecarboxylic acid, 1,1-dimethylethyl ester

Dodavatel: Apollo Scientific

Popis: Methyl-1-boc-3-azetidineacetate

Dodavatel: Apollo Scientific

Popis: 6-Amino-9-(tetrahydropyran-2-yl)-9H-purine

Dodavatel: Thermo Fisher Scientific

Popis: 2'-Deoxyadenosine-5'-monophosphate 98%

Bezpečnostní list Certifikáty

Katalogové číslo: (SIALA55799-1G)

Dodavatel: Merck

Popis: 1-Amino-9-fluorenone, Sigma-Aldrich®

Měrná jednotka: 1 * 1 g

Akce

Dodavatel: MP Biomedicals

Popis: Adenosine-5'-diphosphate monosodium salt (from equine muscle) ≥97%, powder

Dodavatel: Thermo Fisher Scientific

Popis: Dabigatran Etexilate 98%

New Product

Katalogové číslo: (EHERC11305000)

Dodavatel: EHRENSTORFER

Popis: Chlorflurenolmethyl ester(2-chloro-9-hydroxy-9H-fluorene-9-carboxylic acid methyl ester)

Měrná jednotka: 1 * 0,25 g

Akce

Katalogové číslo: (8.20576.0010)

Dodavatel: Merck

Popis: 2-Acetamidofluorene for synthesis

Měrná jednotka: 1 * 10 g

Bezpečnostní list Akce

Katalogové číslo: (ACRO467851000)

Dodavatel: Thermo Fisher Scientific

Popis: Chemical probes can be used to help establish the
relationship between a molecular target and the broader
biological consequences of modulating that target in cells
or organisms.

Měrná jednotka: 1 * 100 mg

Akce

Dodavatel: Merck

Popis: 9-Fluorenylmethanol, Sigma-Aldrich®

Dodavatel: Cayman Chemical

Popis: Adenosine-5'-triphosphate disodium salt (ATP disodium salt)

Dodavatel: Apollo Scientific

Popis: 4-{[(Morpholin-4-yl)carbonyl]amino}benzeneboronic acid, pinacol ester 98%

Dodavatel: Thermo Fisher Scientific

Popis: Adenosine-5'-diphosphate monopotassium salt dihydrate 99%

Bezpečnostní list Certifikáty

Katalogové číslo: (APOSPC8477-100MG)

Dodavatel: Apollo Scientific

Popis: Ethyl 4-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}carbonyl)-5-methylisoxazole-3-carboxylate 97%

Měrná jednotka: 1 * 100 mg

Akce