Hledali jste: polycln

Katalogové číslo: (ABNOPAB10353)

Dodavatel: Abnova

Popis: Rabbit polyclonal antibody raised against Phosphotyrosine.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (ABNOPAB13767)

Dodavatel: Abnova

Popis: Rabbit polyclonal antibody raised against Phosphotyrosine.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (ABNOPAB10352)

Dodavatel: Abnova

Popis: Rabbit polyclonal antibody raised against Phosphothreonine.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (ENZOADIKAPTF120E)

Dodavatel: ENZO LIFE SCIENCES

Popis: Acetylation and methylation of lysine are important post-translational modifications that regulate numerous protein-protein and protein-DNA interactions. Lysine acetylation and methylation involves the transfer of acetylCoA, or one or more methyl groups, to the e-amino group of lysine by modifying enzymes and cofactors. Histones and transcription factors are the primary targets of lysine acetylation and methylation, with either modification capable of inducing gene silencing or expression due to differential regulation of cofactors. For example, varying degrees of mono-, di-, and tri-methylation or acetylation of histone H3 at lysine residue 9 are known to demark distinct chromatin regions during various states of gene activation (methylation) or repression (acetylation).

Měrná jednotka: 1 * 100 µG

New Product Akce

Dodavatel: ENZO LIFE SCIENCES

Popis: Tumor necrosis factor alpha (TNF-α), also known as cachectin, is a 17.5 kDa 157 amino acid member of the TNF superfamily of cytokines that is a potent lymphoid factor with effects on a wide range of target cells. Active TNFalpha is produced in both soluble and membrane-anchored trimers by macrophages, NK cells, and T- and B-lymphocytes. TNF exerts proinflammatory signals via binding and inducing trimerization of TNF-receptor1 (TNF-R1) expressed on most normal and transformed cells, or to TNF-receptor 2 (TNF-R2), expressed on endothelial and most immune cells. TNF signaling regulates hematopeiesis, differentation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune suveillance, and dysregulation of TNF or its receptors is implicated in numerous disease states including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis.

New Product

Katalogové číslo: (ENZOADICSA824E)

Dodavatel: ENZO LIFE SCIENCES

Popis: The TLRs (Toll-like receptors) are a group of evolutionarily conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine-rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands.

Měrná jednotka: 1 * 100 µG

New Product Akce

Dodavatel: ENZO LIFE SCIENCES

Popis: Anti-GRP78 Rabbit Polyclonal Antibody

New Product

Dodavatel: ENZO LIFE SCIENCES

Popis: p23 is a ubiquitous, highly conserved co-chaperone for Hsp90 that participates in the folding of a number of cell regulatory proteins including progesterone and glucocorticoid receptors, HSF1, and telomerase. p23 is thought to modulate Hsp90 activity in the last stages of the chaperoning pathway by binding and stabilizing Hsp90 in its ATP-bound state.

New Product

Katalogové číslo: (AVIVARP43518T10025)

Dodavatel: Aviva Systems Biology

Popis: Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.

Měrná jednotka: 1 * 25 µl

Akce

Dodavatel: ENZO LIFE SCIENCES

Popis: Recombinant PI31 has been shown to compete with the proteasome regulators PA28 and 19S PA700 for binding to 20S, indicating that PI31 binds the 20S α-rings and may function by hindering substrate access to the 20S catalytic channel.

New Product

Dodavatel: ENZO LIFE SCIENCES

Popis: Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately linked with its function. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation.

New Product

Dodavatel: ENZO LIFE SCIENCES

Popis: DnaJ is a basic 41 kDa E. coli Heat shock protein which belongs to the molecular chaperone class of proteins. Bacterial DnaJ protein acts synergistically with the bacterial chaperone DnaK (Hsp70 homologue) and the other co-chaperone GrpE in suppressing eukaryotic and prokaryotic polypeptide aggregation, facilitating protein translocation through intracellular compartments or protein secretion, reactivating some partially aggregated enzymes, and activating pre-priming complex during initiation of DNA replication.

New Product

Dodavatel: ENZO LIFE SCIENCES

Popis: GroEL and GroES are E. coli chaperonins, which are homologs of mitochondrial chaperonins Hsp60 and Hsp10. GroEL is a double toriodal assembly of 14 identical subunits which form two heptameric rings stacked back-to-back, with a cavity at each end. GroEL and its co-chaperonin GroES facilitate protein folding with an ATP-dependent mechanism.

New Product

Dodavatel: ENZO LIFE SCIENCES

Popis: The 104 kDa yeast heat shock protein (Hsp104) is a cytosolic member of the Hsp100 family of proteins. Hsp104 cooperates with Hsp40 and Hsp70 co-chaperones in yeast in the reactivation of heat-damaged proteins. Hsp104 is also critical for the establishment and maintenance of the [PSI] prion phenotype in Saccharomyces cerevesiae.

New Product

Katalogové číslo: (ENZOADI915063100)

Dodavatel: ENZO LIFE SCIENCES

Popis: Cyclic GMP (cGMP), which has been shown to be present at levels typically 10-100 fold lower than cAMP, is formed by the action of the enzyme guanylate cyclase on GTP. Some hormones, such as Acetylcholine, Insulin, and Oxytocin, as well as certain other chemicals like Serotonin and Histamine cause an increase in cGMP levels. Stimulators of guanylate cyclase such as the vasodilators nitroprusside, nitroglycerin, sodium nitrate, and nitric oxide (NO) also stimulate cGMP levels.

Měrná jednotka: 1 * 100 µl

New Product Akce

Katalogové číslo: (ENZOBMLSA3610100)

Dodavatel: ENZO LIFE SCIENCES

Popis: Host: Rabbit

Měrná jednotka: 1 * 100 µl

New Product Akce