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Anti-TNFR1 Rabbit Polyclonal Antibody

Dodavatel: ENZO LIFE SCIENCES
ADICSA815D ADICSA815F
ENZOADICSA815DEA 8700 CZK
ENZOADICSA815D ENZOADICSA815F
Anti-TNFR1 Rabbit Polyclonal Antibody
Protilátky
Tumor necrosis factor alpha (TNF-α), also known as cachectin, is a 17.5 kDa 157 amino acid member of the TNF superfamily of cytokines that is a potent lymphoid factor with effects on a wide range of target cells. Active TNFalpha is produced in both soluble and membrane-anchored trimers by macrophages, NK cells, and T- and B-lymphocytes. TNF exerts proinflammatory signals via binding and inducing trimerization of TNF-receptor1 (TNF-R1) expressed on most normal and transformed cells, or to TNF-receptor 2 (TNF-R2), expressed on endothelial and most immune cells. TNF signaling regulates hematopeiesis, differentation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune suveillance, and dysregulation of TNF or its receptors is implicated in numerous disease states including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis.

  • For Immunoprecipitation, Western Blot

Recognizes human, mouse, rat, bovine, dog, Drosophila, hamster, monkey, pig, rabbit, sheep, Xenopus and yeast TNF-R1. Detects a band of 55kDa by Western blot.

Type: Primary
Antigen: TNFR1
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human
Objednat

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