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L-Biopterin ≥98%

Dodavatel: Thermo Fisher Scientific

Popis: L-Biopterin ≥98%

L-Biopterin ≥98%

Katalogové číslo: (ENZOALX440008M100)

Dodavatel: ENZO LIFE SCIENCES

Popis: L-Biopterin ≥98%

Měrná jednotka: 1 * 100 mg

New Product Akce

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(6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride ≥98% (by HPLC)

Dodavatel: ENZO LIFE SCIENCES

Popis: Cofactor of nitric oxide synthases (NOS).

New Product

Anti-Tyrosine Hydroxylase Rabbit Polyclonal Antibody

Katalogové číslo: (BSENR-148-50)

Dodavatel: Biosensis

Popis: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. FUNCTION: Plays an important role in the physiology of adrenergic neurons. CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. COFACTOR: Fe(2+) ion. ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity. PATHWAY: Catecholamine biosynthesis; first step. SUBUNIT: Homotetramer. PTM: In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation. SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality.

Měrná jednotka: 1 * 50 µG

Akce

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(6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride, powder

Dodavatel: MP Biomedicals

Popis: Soluble in water (2,3 g completely soluble in 100 ml). A 1 mM solution in water results in a pH of 3,0 and 1 M solution in water results in a pH of 0,45.

Biopterin ELISA Kit

Katalogové číslo: (ANTIA247111-96)

Dodavatel: ANTIBODIES.COM

Popis: Biopterin ELISA kit is a competitive Enzyme-Linked Immunosorbent Assay (cELISA) designed for the <i>in vitro</i> quantitative determination of Biopterin in serum, plasma, tissue homogenates, and other biological fluids.

Měrná jednotka: 1 * 96 Tests

New Product Akce

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Human recombinant Tryptophan 5-hydroxylase 2 (from E. coli)

Katalogové číslo: (PRSI92-161)

Dodavatel: ProSci Inc.

Popis: Tryptophan 5-hydroxylase 2 (TPH2) is an isozyme member of the biopterin-dependent aromatic amino acid hydroxylase family. TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression found in the raphe nucleus of the midbrain. TPH2 catalyses the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD). Defects in TPH2 are the cause of psychiatric diseases such as bipolar affective disorder and major depression.

Měrná jednotka: 1 * 50 µG

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