Hledali jste: Akt+inhibitor+VIII

Katalogové číslo: (PRSI33-139)

Dodavatel: ProSci Inc.

Popis: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (alpha and beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIFs regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

Měrná jednotka: 1 * 100 µG

New Product Akce

Katalogové číslo: (PRSI96-410)

Dodavatel: ProSci Inc.

Popis: Insulin-like growth factor 1 (IGF-1) is also known as somatomedin C, IGF1A, IGFI, sulfation factor, and is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. IGF-1 binds to at least two cell surface receptors: the Insulin-like growth factor 1 receptor, abbreviated as "IGF1R", and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor - it binds IGF-1 at significantly higher affinity than the IGF-1 that is bound to the insulin receptor. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. Its primary action is mediated by binding to its specific receptor IGF1R, present on many cell types in many tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6). Specific references are provided for interactions with IGFBP3, IGFBP4 and IGFBP7.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (USBIF0016-10-1)

Dodavatel: US Biological

Popis: Anti-Factor VIII, Human Sheep Polyclonal Antibody

Měrná jednotka: 1 * 1 mg

Akce

Katalogové číslo: (USBI144373)

Dodavatel: US Biological

Popis: Anti-Coagulation factor VIII Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µG

Akce

Dodavatel: VWR Collection

Popis: Acetal polymer. Používané pro identifikaci vzorků tkáně v oblasti zpracování, zalévání a krájení. Odolné vůči všem běžně používaným histologickým roztokům. Mega kazety s přitaveným víčkem. Krabice obsahuje 100 kazet.

Katalogové číslo: (USBIV2700-04C)

Dodavatel: US Biological

Popis: Anti-Factor VIII Related Antigen Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 1 mL

Akce

Katalogové číslo: (87047.180)

Dodavatel: VWR Chemicals

Popis: Standardy víceprvkové, ICP multi-element standard solution VIII, 24 elements, 100 mg/L each of Al; B; Ba; Be; Bi; Ca; Cd; Co; Cr; Cu; Fe; Ga; K; Li; Mg; Mn; Na; N ; Pb; Se; Sr; Te; Tl; Zn, VWR® ARISTAR®, Matrice: 2% HNO₃, Aplikace: Standardy ICP

Měrná jednotka: 1 * 100 mL

Bezpečnostní list Certifikáty Akce

Dodavatel: Thermo Fisher Scientific

Popis: Kyselina osmiová 2,5% (w/w) in tert-butanol stabilised

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Dodavatel: Thermo Fisher Scientific

Popis: Kyselina osmiová 4% (w/w) in water

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Katalogové číslo: (USBIN0590-15D)

Dodavatel: US Biological

Popis: Anti-Nei Endonuclease VIII-like 3 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Thermo Fisher Scientific

Popis: Kyselina osmiová 4% in aqueous solution

Bezpečnostní list Certifikáty

Dodavatel: Thermo Fisher Scientific

Popis: Kyselina osmiová 99.9+% (trace metals basis)

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Dodavatel: Thermo Fisher Scientific

Popis: Kyselina osmiová 99.8% (≥74.4% Os) (metals basis)

Bezpečnostní list Certifikáty

Katalogové číslo: (NOVUNB100-91761)

Dodavatel: Novus Biologicals

Popis: The Factor VIII Antibody from Novus Biologicals is a rabbit polyclonal antibody to Factor VIII. This antibody reacts with human, mouse, rat. The Factor VIII Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.

Měrná jednotka: 1 * 100 µG

Akce

Dodavatel: Thermo Fisher Scientific

Popis: Kyselina osmiová 2% in aqueous solution

Bezpečnostní list Certifikáty

Dodavatel: Thermo Fisher Scientific

Popis: CAS No.: 1176-74-5

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