Hledali jste: ackr2

Katalogové číslo: (BOSSBS-7119R-CY5.5)

Dodavatel: Bioss

Popis: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12128R-CY7)

Dodavatel: Bioss

Popis: Acid sensing ion channel ASIC1 is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12128R-CY3)

Dodavatel: Bioss

Popis: Acid sensing ion channel ASIC1 is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI031587-BIOTIN)

Dodavatel: US Biological

Popis: Anti-ACTR6 Rabbit Polyclonal Antibody (Biotin)

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (BOSSBS-7952R-CY7)

Dodavatel: Bioss

Popis: ADCK2 (aarF domain containing kinase 2), also known as AARF, is a 626 amino acid single-pass membrane protein belonging to the protein kinase superfamily and the ADCK protein kinase family. The ADCK family consists of five paralogs in human (ADCK1-5). Encoded by a gene that maps to human chromosome 7q34, ADCK2 contains one protein kinase domain. ADCK2 participates in ATP and nucleotide binding, transferase functions and protein serine/threonine kinase activities. Expression of ADCK2 inversely correlates with cellular viability, suggesting elevated expression of ADCK2 may be essential for tumour survival. ADCK2 is necessary for cell proliferation of glioblastoma multiforme (GBM), a fatal primary brain tumor containing countless genetic and epigenetic alterations.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2490R-CY3)

Dodavatel: Bioss

Popis: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2490R-CY5.5)

Dodavatel: Bioss

Popis: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2133R-CY7)

Dodavatel: Bioss

Popis: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2133R-CY3)

Dodavatel: Bioss

Popis: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (ANTIA75214-96)

Dodavatel: ANTIBODIES.COM

Popis: Human ASGR2 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human ASGR2 in serum, plasma, tissue homogenates, and other biological fluids.

Měrná jednotka: 1 * 96 Tests

New Product Akce

Katalogové číslo: (ANTIA86996-96)

Dodavatel: ANTIBODIES.COM

Popis: Bovine ACTG2 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of bovine ACTG2 in serum, plasma, tissue homogenates, and other biological fluids.

Měrná jednotka: 1 * 96 Tests

New Product Akce

Katalogové číslo: (ANTIA311666-96)

Dodavatel: ANTIBODIES.COM

Popis: Human ACTG2 ELISA kit is a 90 minute sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human ACTG2 in serum, plasma, and other biological fluids.

Měrná jednotka: 1 * 96 Tests

New Product Akce

Katalogové číslo: (BOSSBS-12417R-CY5)

Dodavatel: Bioss

Popis: Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12416R-CY7)

Dodavatel: Bioss

Popis: Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1-6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12416R-CY3)

Dodavatel: Bioss

Popis: Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1-6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (EVBIEB08207-B)

Dodavatel: Everest Biotech

Popis: Anti-ACVR1 Goat Polyclonal Antibody (Biotinylated)

Měrná jednotka: 1 * 0,1 mg

Akce