Hledali jste: ackr2

Katalogové číslo: (BOSSBS-12415R-CY3)

Dodavatel: Bioss

Popis: Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1–6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12417R-CY7)

Dodavatel: Bioss

Popis: Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-5030R-CY7)

Dodavatel: Bioss

Popis: ACOX2

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-5030R-CY5.5)

Dodavatel: Bioss

Popis: ACOX2

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBIA0855-97-BIOT)

Dodavatel: US Biological

Popis: Anti-ACVR2B Rabbit Polyclonal Antibody (Biotin)

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (USBI038967-BIOTIN)

Dodavatel: US Biological

Popis: Anti-HCAR2 Rabbit Polyclonal Antibody (Biotin)

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (USBI031552-BIOTIN)

Dodavatel: US Biological

Popis: Anti-ACPL2 Rabbit Polyclonal Antibody (Biotin)

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (USBI031570-BIOTIN)

Dodavatel: US Biological

Popis: Anti-ACTG2 Rabbit Polyclonal Antibody (Biotin)

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (ABGEAP12667C)

Dodavatel: Abgent

Popis: Anti-GPR109A Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 400 µl

Akce

Katalogové číslo: (USBIA0855-95H)

Dodavatel: US Biological

Popis: Anti-ACVR1 Goat Polyclonal Antibody

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (USBIC2274-05B)

Dodavatel: US Biological

Popis: Anti-FCER2 Rat monoclonal antibody

Měrná jednotka: 1 * 500 µG

Akce

Katalogové číslo: (ABGEAP9464A)

Dodavatel: Abgent

Popis: Anti-DBC1 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 400 µl

Akce

Katalogové číslo: (ABGEAP13908C)

Dodavatel: Abgent

Popis: Anti-ACVR2B Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 400 µl

Akce

Katalogové číslo: (EVBIEB12626)

Dodavatel: Everest Biotech

Popis: Anti-AMHR2 Goat Polyclonal Antibody

Měrná jednotka: 1 * 0,1 mg

Akce

Katalogové číslo: (BOSSBS-10367R)

Dodavatel: Bioss

Popis: Anti-ACTN2 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (AVIVARP55491_P050)

Dodavatel: Aviva Systems Biology

Popis: Anti-AMER2 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 50 µG

Akce