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Y-27632 dihydrochloride

Dodavatel: Apollo Scientific

Popis: Y-27632 dihydrochloride is a selective ROCK1 p160ROCK inhibitor with Ki of 140 nM exhibits 200-fold selectivity over other kinases including PKC cAMP-dependent protein kinase MLCK and PAK.

Y-27632 dihydrochloride ≥98% (by HPCE)

Dodavatel: ENZO LIFE SCIENCES

Popis: ROCK inhibitor

New Product

Y-27632 dihydrochloride

Dodavatel: Cayman Chemical

Popis: Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nm) and ROCK-II (IC<sub>50</sub> = 800 nm). It also inhibits PRK2 with an IC<sub>50</sub> value of 600 nm.

H-1152 dihydrochloride ≥98% (by HPLC)

Dodavatel: ENZO LIFE SCIENCES

Popis: A cell permeable, highly specific, potent and ATP-competitive inhibitor of Rho kinase (ROCK) (Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA, 9.27mM for PKC and 10.1mM for MLCK). More potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid. Inhibits EP3-stimulated NO formation. Prevents fragmentation of apoptotic cells. Relieves neuropathic pain.

New Product

Y-27632 dihydrochloride 99%

Katalogové číslo: (470701000.)

Dodavatel: Thermo Scientific

Popis: Y-27632 dihydrochloride 99%

Měrná jednotka: 1 * 100 mg

New Product Akce

N/A Each

Rockout ≥98% (by HPLC)

Katalogové číslo: (ENZOALX270429M005)

Dodavatel: ENZO LIFE SCIENCES

Popis: A cell permeable, selective, and ATP-competitive inhibitor of Rho kinase (ROCK) activity (IC50=25µM). Does not inhibit the activation of Rho nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be less potent than Y-27632.

Měrná jednotka: 1 * 5 mg

New Product Akce