Hledali jste: Thymidine-5\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'-monophosphate+disodiu

Dodavatel: Thermo Scientific

Popis: Thymidine-5'-monophosphate disodium salt

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Katalogové číslo: (PRSI92-370)

Dodavatel: ProSci Inc.

Popis: Thymidylate kinase (DTYMK) is a ubiquitous enzyme of about 25 kD which belongs to thymidylate kinase family. DTYMK is important in the dTTP synthesis pathway for DNA synthesis. It participated in the pyrimidine metabolism pathway and dTTP biosynthesis pathway. DTYMK catalyses the conversion of dTMP to dTDP and catalyses the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSI30-425)

Dodavatel: ProSci Inc.

Popis: TYMS catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-47 CR601528.1 1-47 48-1099 X02308.1 14-1065 1100-1603 BC083512.1 1067-1570

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSI26-754)

Dodavatel: ProSci Inc.

Popis: ENPP6 is a choline-specific glycerophosphodiester phosphodiesterase. ENPP6 hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. ENPP6 hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. ENPP6 has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently.

Měrná jednotka: 1 * 50 µG

Akce

Dodavatel: Thermo Scientific

Popis: Thymidine (2'-deoxythymidine) 99+%

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Katalogové číslo: (APOSBIT2044-25G)

Dodavatel: Apollo Scientific

Popis: Thymidine (2'-deoxythymidine)

Měrná jednotka: 1 * 25 g

Akce

Dodavatel: Apollo Scientific

Popis: 5'-O-(4,4'-Dimethoxytrityl)thymidine 98%

Dodavatel: Thermo Scientific

Popis: β-L-Thymidine

Dodavatel: Thermo Scientific

Popis: Thymidine (2'-deoxythymidine) ≥99%

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Dodavatel: Thermo Scientific

Popis: 5'-O-(4,4'-Dimethoxytrityl)thymidine ≥98%

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Katalogové číslo: (H52301.03)

Dodavatel: Thermo Scientific

Popis: 5'-O-(tert-Butyldimethylsilyl)thymidine ≥97%

Měrná jednotka: 1 * 1 g

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Katalogové číslo: (BOSSBS-3809R-A488)

Dodavatel: Bioss

Popis: In the presence of inorganic orthophosphate, the platelet-derived endothelial growth factor (PD-ECGF) thymidine phosphorylase (TP) (gliostatin) catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-3809R-A350)

Dodavatel: Bioss

Popis: In the presence of inorganic orthophosphate, the platelet-derived endothelial growth factor (PD-ECGF) thymidine phosphorylase (TP) (gliostatin) catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-0917R-CY5)

Dodavatel: Bioss

Popis: Bromodeoxyuridine is a synthetic nucleoside that is an analogue of thymidine. BrdU is incorporated into DNA during S-phase of a cell cycle. It is commonly used in the detection of proliferating cells in living tissues

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-6584R-CY5)

Dodavatel: Bioss

Popis: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Thermo Scientific

Popis: Adenosine-3',5'-cyclic monophosphate (cAMP) 99+%

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