Hledali jste: Ob\u00E1lky

Katalogové číslo: (PRSIXW-7340)

Dodavatel: ProSci Inc.

Popis: Leptin; leptin (murine obesity homolog); obesity. Leptin, a product of the Obese (ob) gene, is a ligand for the OB receptor (OC-R). Mice with mutations of the ob gene have been found to be obese and diabetic and to have reduced activity, metabolism, and body temperature. M.W: 16,000.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PMPC25-8081PR)

Dodavatel: PURITAN MEDICAL

Popis: Extra-absorbent oversized rayon tipped applicator with plastic handle.

Měrná jednotka: 1 * 500 KS

Certifikáty Akce

Katalogové číslo: (BOHLR1203-01)

Dodavatel: Bohlender

Popis: The grip position indicates if the passage is open or closed.

Měrná jednotka: 1 * 1 KS

Akce

Katalogové číslo: (PRSI96-691)

Dodavatel: ProSci Inc.

Popis: Sialic acid-binding Ig-like lectin 5 (SIGLEC5) is also known as CD33 antigen-like 2 (CD33L2), Obesity-binding protein 2 (OB-BP2), CD antigen CD170, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC5 / CD170 is expressed by monocytic / myeloid lineage cells. SIGLEC-5 / CD33-L2 binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Měrná jednotka: 1 * 100 µG

Akce

Dodavatel: VWR Chemicals

Popis: These standards are ideal to use as control standards for COD measurements to verify that correct analysis for COD has taken place.

Bezpečnostní list Certifikáty

Katalogové číslo: (PRSI5647)

Dodavatel: ProSci Inc.

Popis: Slc37A2 Antibody: The Slc37 gene family consists of four members which have 10-12 predicted transmembrane domains and belong to the sugar-phosphate transporter superfamily. Recent experiments have demonstrated that Slc37A2 is a macrophage-specific gene selectively expressed in obese white adipose tissue. Its transcript is also expressed in spleen and thymus and the cell lines RAW264.7 and THP-1. Compared to wild-type mice, Slc37A2 mRNA is expressed at nine-fold higher levels in abdominal epididymal fat deposits of ob/ob mice, suggesting that it may be required to limit the contribution of macrophages to the inflammatory state present in obesity. Slc37A2 protein is post-translationally modified with the addition of N-linked glycans and migrates as a heterogeneous species of 50-75kDa.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSI3557)

Dodavatel: ProSci Inc.

Popis: CTRP1 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice.

Měrná jednotka: 1 * 100 µG

Akce

Dodavatel: CHIRAL TECHNOLOGIES

Popis: These columns are packed with Daicel’s coated polysaccharide-based chiral stationary phases (CSPs) which are manufactured by physically coating the polysaccharide derivatives onto silica matrices. Due to this manufacturing process, a choice of mobile phase components is typically narrower than with immobilised columns in order to minimise damage to the CSPs.

Katalogové číslo: (PRSI92-612)

Dodavatel: ProSci Inc.

Popis: Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signalling pathways involving OB-R in hypothalamus. In mammals, leptin is mainly produced by the adipose tissue and encodes body fat reserves, acting as a short-term satiety signal. In fish, the presence of a leptin-like peptide was first evidenced by immuno-cross-reactivity [14], and its existence was certainly demonstrated after the finding by synteny of a leptin sequence in the pufferfish.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSI3555)

Dodavatel: ProSci Inc.

Popis: CTRP1 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSI91-053)

Dodavatel: ProSci Inc.

Popis: Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin deficient mice are less active and with lower body temperature than normal animals. Human Leptin shares approximately 84% sequence identity with the mouse protein. Human Leptin consists of 167 amino acid residue including a 21 amino acid residue signal sequence and 146 amino acid residue mature protein sequence.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSIXP-5211)

Dodavatel: ProSci Inc.

Popis: Leptin plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in Leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. The Leptin gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSI96-513)

Dodavatel: ProSci Inc.

Popis: Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSIXP-5213)

Dodavatel: ProSci Inc.

Popis: Leptin plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in Leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. The Leptin gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSIXP-5212BT)

Dodavatel: ProSci Inc.

Popis: Leptin plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in Leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. The Leptin gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSI38-235)

Dodavatel: ProSci Inc.

Popis: Leptin plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in Leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. The Leptin gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.
Was product number XP-5712-M

Měrná jednotka: 1 * 500 µG

Akce