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Popis: Recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

Katalogové číslo: BNUB0880-100

Měrná jednotka: 1 * 100 µl

Dodavatel: Biotium

Akce

Popis: Recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

Katalogové číslo: BNC880880-100

Měrná jednotka: 1 * 100 µl

Dodavatel: Biotium

Akce

Popis: Di-4-ANEPPS is a fast-responding membrane potential dye. Changes in the membrane potential of the cell correlate with changes in the fluorescence excitation intensity of the dye.

Katalogové číslo: 61010.

Měrná jednotka: 1 * 5 mg

Dodavatel: Biotium

Akce

Popis: Tissue float bath for stretching and drying cut tissue samples. Working temperature range of the histology bath is 25 to 80 °C.

Katalogové číslo: 462-0624

Měrná jednotka: 1 * 1 KS

Dodavatel: LAUDA

Akce

Popis: These fused quartz slides are made of fusing naturally occurring crystalline silica.

Katalogové číslo: 42296.KJ

Měrná jednotka: 1 * 5 KS

Dodavatel: Thermo Fisher Scientific

Bezpečnostní list Certifikáty Akce

Popis: Decalcifier according to Kristenson.

Katalogové číslo: 352432C

Měrná jednotka: 1 * 5 L

Dodavatel: VWR Chemicals

Bezpečnostní list Certifikáty Akce

Popis: These microscope slides are designed for applications in cell culture.

Katalogové číslo: 734-2070

Měrná jednotka: 1 * 100 KS

Dodavatel: Thermo Fisher Scientific

Akce

Popis: Plan achromatic and phase contrast objectives.

Katalogové číslo: LEIM11506230

Měrná jednotka: 1 * 1 KS

Dodavatel: LEICA MICROSYSTEMS

Akce

Popis: Selected proven glass quality.

Katalogové číslo: HECH91240000252

Měrná jednotka: 1 * 1.000 KS

Dodavatel: GLASWARENFABRIK KARL HECHT

Akce

Popis: Biotin-4-fluorescein (N-(5-aminopentyl)biotinamide, trifluoroacetic acid salt) has been reported to be a superior fluorescent biotin derivative for accurate measurement of avidin and streptavidin in crude biological samples. Binding of biotin to avidin and streptavidin is high affinity, fast and noncooperative.

Katalogové číslo: 90062.

Měrná jednotka: 1 * 10 mg

Dodavatel: Biotium

Akce

Popis: Glypican-3 (GPC3) is an integral membrane protein that is mutated in the Simpson-Golabi-Behmel syndrome (SGBS). SGBS is characterized by pre- and post-natal overgrowth and is a recessive X-linked condition.GPC3 may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression has also been found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma was significantly higher than that of follicular adenoma. In contrast, GPC 3 is not expressed in anaplastic carcinoma.

Katalogové číslo: BNC040864-100

Měrná jednotka: 1 * 100 µl

Dodavatel: Biotium

Akce

Popis: Glypican-3 (GPC3) is an integral membrane protein that is mutated in the Simpson-Golabi-Behmel syndrome (SGBS). SGBS is characterized by pre- and post-natal overgrowth and is a recessive X-linked condition.GPC3 may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression has also been found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma was significantly higher than that of follicular adenoma. In contrast, GPC 3 is not expressed in anaplastic carcinoma.

Katalogové číslo: BNC680864-500

Měrná jednotka: 1 * 500 µl

Dodavatel: Biotium

Akce

Popis: Fluorescein biotin (5-((N-(5-(N-(6-(Biotinoyl)amino)hexanoyl)amino)pentyl)thioureidyl) fluorescein) can be used to detect and quantify biotin binding sites and the degree of biotinylation of proteins.

Katalogové číslo: 80019.

Měrná jednotka: 1 * 5 mg

Dodavatel: Biotium

Akce

Popis: Hydroxystilbamidine (also called Fluoro-Gold™) has been used extensively as a retrograde tracer for neurons and also a histochemical stain. The 4% solution in deionized H2O is a convenient, ready-to-use form..

Katalogové číslo: 80023.

Měrná jednotka: 1 * 200 µl

Dodavatel: Biotium

Akce

Popis: Cut or ground edges (90°) slides for microscopy.

Katalogové číslo: HIRS8210103

Měrná jednotka: 1 * 1.000 KS

Dodavatel: HIRSCHMANN

Akce

Popis: These microscope slides feature highly visible blue rings (Ø 14mm).

Katalogové číslo: MARI1613100

Měrná jednotka: 1 * 10 KS

Dodavatel: MARIENFELD

Akce