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Katalogové číslo: (PRSI38-235)

Dodavatel: ProSci Inc.

Popis: Leptin plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in Leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. The Leptin gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.
Was product number XP-5712-M

Měrná jednotka: 1 * 500 µG

Akce

Katalogové číslo: (PRSI92-138)

Dodavatel: ProSci Inc.

Popis: CST Complex Subunit STN1 (OBFC1) is a 368 amino acid protein that contains one OB DNA-binding domain. It is a member of the STN1 family. OBFC1 is component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSI92-612)

Dodavatel: ProSci Inc.

Popis: Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signalling pathways involving OB-R in hypothalamus. In mammals, leptin is mainly produced by the adipose tissue and encodes body fat reserves, acting as a short-term satiety signal. In fish, the presence of a leptin-like peptide was first evidenced by immuno-cross-reactivity [14], and its existence was certainly demonstrated after the finding by synteny of a leptin sequence in the pufferfish.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSI3555)

Dodavatel: ProSci Inc.

Popis: CTRP1 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice.

Měrná jednotka: 1 * 100 µG

Akce

Dodavatel: VWR Chemicals

Popis: These standards are ideal to use as control standards for COD measurements to verify that correct analysis for COD has taken place.

Bezpečnostní list Certifikáty

Katalogové číslo: (PRSIXP-5213)

Dodavatel: ProSci Inc.

Popis: Leptin plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in Leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. The Leptin gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSIXP-5211)

Dodavatel: ProSci Inc.

Popis: Leptin plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in Leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. The Leptin gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSIXP-5212BT)

Dodavatel: ProSci Inc.

Popis: Leptin plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in Leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. The Leptin gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSI91-053)

Dodavatel: ProSci Inc.

Popis: Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin deficient mice are less active and with lower body temperature than normal animals. Human Leptin shares approximately 84% sequence identity with the mouse protein. Human Leptin consists of 167 amino acid residue including a 21 amino acid residue signal sequence and 146 amino acid residue mature protein sequence.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSI96-513)

Dodavatel: ProSci Inc.

Popis: Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSI96-692)

Dodavatel: ProSci Inc.

Popis: Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is also known as CD antigen CD327, CD33 antigen-like 1 (CD33L or CD33L1), Obesity-binding protein 1 (OB-BP1). SIGLEC6 belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family, which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIGLEC6 mediates sialic-acid dependent binding to cells. SIGLEC6 binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (MULC1368)

Dodavatel: MULTIROIR

Popis: Certified BPA-free, this airtight container is ideal for transporting and securely storing products, whether liquid or solid in form.

Měrná jednotka: 1 * 12 KS

Akce

Katalogové číslo: (MULC104461)

Dodavatel: MULTIROIR

Popis: This wide three-drawer polypropylene tower is ideal for storing various materials, whether they are consumables or stationery.

Měrná jednotka: 1 * 1 KS

Akce

Dodavatel: BURKLE

Popis: Standard close-it and close-it food & pharma control seals are also available on a continuous roll. This offers the flexibility to provide a small length of tape to seal a small hole or to mark a specific point. Alternatively, longer pieces can be used to repair a long tear quickly, reliably and easily. With its extremely strong adhesive strength, close-it tapes adhere to a range of different surfaces, where the glue effect of normal adhesive tape quickly reaches its maximum capacity.

Dodavatel: REAGECON

Popis: Ideal for use as control standards to verify that correct analysis for COD has taken place.

Dodavatel: Brand

Popis: The accu-jet® S pipette controller brings versatility and endurance to your team. It makes lab work simple, easy, and efficient, whether you work with cell cultures, in quality control or in a pharma lab.

Akce