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Anti-HIF1A Mouse Monoclonal Antibody (CF647) [clone: HIF1A-84]

Dodavatel: Biotium
Popis: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

Product Image-HACH2212242

Reagents for DR800, DR900, DR2010, DR2500, DR2400, DR2800, DR3800, DR3900, DR5000, DR6000

Dodavatel: Hach
Popis: Reagents for photometric analysis either in field conditions or in the laboratory.

Image Unavailable-ICNA0219459280

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) ≥98%, yellow powder cell culture reagent

Dodavatel: MP Biomedicals
Popis: Storage: +4°C, protect from light
3- (4,5-Dimethyl-2-thiazolyl-2)-2,5-diphenyl-tetrazolium bromide is used as a colorimetric metabolic activity indicator in cell viability assays. Thiazolyl Blue Tetrazolium Blue (MTT) is a dye used in measurement of cell proliferation. MTT produces a yellowish solution that is converted to dark blue, water-insoluble MTT formazan by mitochondrial dehydrogenases of living cells. The blue crystals are solubilized with acidified isopropanol and the intensity is measured colorimetrically at 570 nm. MTT has been used as a histochemical/cytochemical reagent and for the detection of NAD. ADP-linked enzyme systems in tissue cannot be detected with MTT, due to binding of the cation by the cyanide trap used. MTT is rapidly reduced to the formazan, which chelates with nickel, copper, and cobalt; the cobalt chelate has been used in oxidative systems.

Bezpečnostní list

Image Unavailable-BNC880084-100

Anti-HIF1A Mouse Monoclonal Antibody (CF488A) [clone: HIF1A-84]

Dodavatel: Biotium
Popis: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

Image Unavailable-BNC940084-100

Anti-HIF1A Mouse Monoclonal Antibody (CF594) [clone: HIF1A-84]

Dodavatel: Biotium
Popis: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

Image Unavailable-BNC400084-500

Anti-HIF1A Mouse Monoclonal Antibody (CF640R) [clone: HIF1A-84]

Dodavatel: Biotium
Popis: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

Product Image-BOHLC365-20

Magnetic stirring bars, power, PTFE, BOLA

Dodavatel: Bohlender
Popis: Magnetic stirrer bars with magnetic core of samarium-cobalt encapsulated in PTFE. Torque loads transmitted with these stirring bars are four times larger than conventional magnetic stirring bars.

Image Unavailable-BNCB0084-100

Anti-HIF1A Mouse Monoclonal Antibody (Biotin) [clone: HIF1A-84]

Dodavatel: Biotium
Popis: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

Product Image-PRSI30-803

Anti-METAP2 Rabbit Polyclonal Antibody

Katalogové číslo: (PRSI30-803)
Dodavatel: ProSci Inc.
Popis: METAP2 is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site.This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Měrná jednotka: 1 * 50 µG
Product Image-BELAF371020238

Magnetic stirring bars, octagonal, rare earth, Spinbar®, SP Bel-Art

Dodavatel: Bel-Art Products, a Part of SP
Popis: These stirring bars reduce the frequency of spinout in viscous solutions or when stirring at high speeds. The high magnetic field strength of samarium cobalt (Rare Earth) magnets can provide up to three times stronger coupling versus Alnico magnetic stirring bars. Stronger coupling with the drive magnet keeps the stirring bar centered and rotating effectively.

Product Image-IKAA4493200

Sada magnetických tyčových míchadel, IKAFLON®

Dodavatel: IKA
Popis: Tyčová míchadla potažená vrstvou skla nebo PTFE Použitelná v široké škále aplikací. K dispozici 5/sada nebo 1/sada.

Product Image-BELAF371740000

Magnetic stirring bars, octagonal, rare earth, PTFE, Spinbar®, SP Bel-Art

Katalogové číslo: (BELAF371740000)
Dodavatel: Bel-Art Products, a Part of SP
Popis: <B>PTFE</B> covered samarium cobalt magnet provides strong coupling with drive magnets making it ideal for use with viscous solutions and efficient, high speed stirring. The fluted octagonal shape creates torque transmission rates to the stirred liquid which are two to three fold higher compared to similarly sized standard stirring bars.
Měrná jednotka: 1 * 1 KS
Image Unavailable-1.10002.0001

Test strips for cobalt, MQuant®, Supelco®

Katalogové číslo: (1.10002.0001)
Dodavatel: Merck
Popis: MQuant® (MQ) test strips can be considered as a mobile laboratory on a few square millimeters of plastic strip. As a screening method they provide the user with a rapid overview of the situation, which helps in making the choice of what, and perhaps if, further analysis is required, thereby leading to potentially substantial savings in time and analytical resources. The strip is a biologically-degradable polyester foil and the low reagent content, in the reaction zones, assists problem-free waste disposal.
Měrná jednotka: 1 * 100 Tests

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Product Image-29-0005-96

Filtrační destičky, 96-jamek, His MultiTrap™ TALON®

Katalogové číslo: (29-0005-96)
Dodavatel: Cytiva
Popis: Mnohojamkové destičky His MultiTrap™ TALON® jsou navrženy pro vysoce výkonný screening proteinu označeného histidinem od klarifikovaného buněčného lyzátu. Předbalené destičky His MultiTrap™ TALON® jsou vyrobeny s velkou reprodukovatelností a ohledem na objemy jamek a médií pro konzistentní výsledky.Průměrná čistota His MultiTrap TALON® je >85% s výtěžkem až 1 mg/jamka. Únik kobaltových iontů z média TALON® Superflow™ je zanedbatelný. Destičky His MultiTrap™ TALON® jsou používány manuálně s vakuem nebo odstřeďováním, nebo v kapalné manipulační stanici.
Měrná jednotka: 1 * 4 KS
Product Image-633-0022

Comparator kits, Lovibond® system 2000

Dodavatel: Lovibond Tintometer
Popis: Available for many of the commonly used colour scales, these kits are a convenient means of ordering the complete range of equipment required. Each system includes.

Image Unavailable-GREI456080_1200

Blood collection tubes with NH trace elements sodium heparin, VACUETTE®

Katalogové číslo: (GREI456080_1200)
Dodavatel: Greiner Bio-One
Popis: Tubes are designed to test trace elements such as aluminium, lead, cadmium, chrome, iron, fluoride, cobalt, copper, lithium, manganese, molybdenum, mercury, selenium, or thallium etc.
Měrná jednotka: 1 * 1.200 KS
Cena na vyžádání
Omezené množství produktu na skladě. Zboží může být k dispozici v jiném skladě poblíž vašeho sídla. Přesvědčte se, že jste přihlášení na stránky, abyste mohli vidět dostupné položky na skladě. Pokud je stále zobrazeno call a potřebujete asistenci, volejte na číslo 321 570 321.
Omezené množství produktu na skladě. Zboží může být k dispozici v jiném skladě poblíž vašeho sídla. Přesvědčte se, že jste přihlášení na stránky, abyste mohli vidět dostupné položky na skladě. Pokud je stále zobrazeno call a potřebujete asistenci, volejte na číslo 321 570 321.
Daná chemikálie je regulována dle platné legislativy a bude vyžadováno vyplnění formuláře. Jeho včasným vyplněním uspíšíte dodání produktu.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Tento produkt je zablokován vaší organizací. Kontaktujte své nákupní oddělení pro více informací.
Původní produkt již není k dispozici. Zobrazen je náhradní produkt.
Tento produkt již není k dispozici. Podobné produkty můžete vyhledat pomocí VWR katalogových čísel nebo čísel dodavatele uvedených výše. Pokud potřebujete další asistenci, zavolejte na telefonní číslo zákaznického servisu VWR 321 570 321.
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