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Anti-HIF1A Mouse Monoclonal Antibody (CF488A) [clone: HIF1A-84]

Dodavatel: Biotium
BNC880084-500 BNC880084-100
BNC880084-500EA 15940 CZK
BNC880084-500 BNC880084-100
Anti-HIF1A Mouse Monoclonal Antibody (CF488A) [clone: HIF1A-84]
Protilátky
HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

Type: Primary
Antigen: HIF1A
Clonality: Monoclonal
Clone: HIF1A-84
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
Objednat

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