Hledali jste: Boc-5-bromo-DL-tryptophan

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Kyselina DL-jablečná ≥99%, TECHNICAL

Katalogové číslo: (20365.290)

Dodavatel: VWR Chemicals

Popis: Kyselina DL-jablečná ≥99%, TECHNICAL

Měrná jednotka: 1 * 1 kg

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DL-Cysteine 96%

Dodavatel: Thermo Fisher Scientific

Popis: DL-Cysteine 96%

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DL-Arabinose ≥98%

Dodavatel: Thermo Fisher Scientific

Popis: DL-Arabinose ≥98%

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Anti-SPR Rabbit Polyclonal Antibody (Cy3®)

Katalogové číslo: (BOSSBS-11784R-CY3)

Dodavatel: Bioss

Popis: SPR, also known as sepiapterin reductase, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family. SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives. In addition, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the final reduction step of the synthesis pathway. BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) and is required for proper dopamine synthesis. Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, a monoamine neurotransmitter deficiency without hyperphenylalaninemia. Sepiapterin reductase deficiency interferes with BH4 synthesis, resulting in DOPA-responsive dystonia and a variety of other human diseases. In addition, SPR mRNA expression is increased in the brain of Parkinsonâ€™s Disease (PD) patients, suggesting that SPR may play a role in PD.

Měrná jednotka: 1 * 100 µl

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DL-Valin ≥99%

Dodavatel: Thermo Fisher Scientific

Popis: DL-Valin ≥99%

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Anti-PWP2 Rabbit Polyclonal Antibody

Katalogové číslo: (USBI040699)

Dodavatel: US Biological

Popis: Anti-PWP2 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 200 µl

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DL-Threonine ≥99%

Dodavatel: Thermo Fisher Scientific

Popis: DL-Threonine ≥99%

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DL-Tyrosine ≥98%

Dodavatel: Thermo Fisher Scientific

Popis: DL-Tyrosine ≥98%

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Human recombinant Tryptophan 5-hydroxylase 2 (from E. coli)

Katalogové číslo: (PRSI92-161)

Dodavatel: ProSci Inc.

Popis: Tryptophan 5-hydroxylase 2 (TPH2) is an isozyme member of the biopterin-dependent aromatic amino acid hydroxylase family. TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression found in the raphe nucleus of the midbrain. TPH2 catalyses the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD). Defects in TPH2 are the cause of psychiatric diseases such as bipolar affective disorder and major depression.

Měrná jednotka: 1 * 50 µG

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N/A Each

DL-Izoleucin ≥99%

Dodavatel: Thermo Fisher Scientific

Popis: DL-Izoleucin ≥99%

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Recombinant TDO Anopheles gambiae (from E. coli)

Katalogové číslo: (PRSI90-359)

Dodavatel: ProSci Inc.

Popis: Tryptophan 2,3-dioxygenase (TDO) is a heme-containing dioxygenase catalyzing the addition of molecular oxygen across the 2,3-double bond of the indole ring of tryptophan to form N-formylkynurenine (NFK). In Anopheles gambiae, TDO is the only enzyme able to catalyze the first and rate-limiting step in L-Trp catabolism through the kynurenine pathway. Tryptophan is an essential amino acid for protein synthesis and also the precursor for production of a number of neurotransmitters, such as serotonin and melatonin; in mosquitoes, the kynurenine pathway is essential for eye pigmentation. Conceivably, the tryptophan-using pathways should be regulated in a coordinated manner in mosquitoes as well as in other species and TDO activation/inactivation processes could play an essential role in these phenomena.

Měrná jednotka: 1 * 50 µG

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