Hledali jste: Akt+inhibitor+VIII

Dodavatel: ENZO LIFE SCIENCES

Popis: Potent inhibitor of Akt1, Akt2 and Akt3 activity.

New Product

Dodavatel: ENZO LIFE SCIENCES

Popis: HDAC6 inhibitor

New Product

Dodavatel: ENZO LIFE SCIENCES

Popis: Akt inhibitor

New Product

Katalogové číslo: (ENZOADIEKS400A)

Dodavatel: ENZO LIFE SCIENCES

Popis: This is a non-radioactive Akt kinase activity assay, providing a safe, rapid and reliable method for the screening of inhibitors or activators of Akt and for quantitating the activity of Akt in purified or partially purified enzyme preparations. The Akt Kinase activity kit is based on a solid phase enzyme immunoassay (EIA) that utilizes a specific synthetic peptide as a substrate for Akt and a polyclonal antibody that recognizes the phosphorylated form of the substrate. The assay is designed for the analysis of Akt (1, 2, 3) activity in the solution phase.

Měrná jednotka: 1 * 1 KIT

New Product Akce

Katalogové číslo: (ENZOENZCHM1260001)

Dodavatel: ENZO LIFE SCIENCES

Popis: Selective inhibitor of Akt (PKB).

Měrná jednotka: 1 * 1 mg

New Product Akce

Dodavatel: ENZO LIFE SCIENCES

Popis: Inhibitor of PI3Kγ, PI3Kδ, FRAP, Akt and VEGF.

New Product

Dodavatel: ENZO LIFE SCIENCES

Popis: Akt inhibitor

New Product

Katalogové číslo: (ENZOALX260155M001)

Dodavatel: ENZO LIFE SCIENCES

Popis: Selective cell permeable inhibitor of PKCzeta. Activates eNOS (NOS III) through Akt phosphorylation and can be considered as a nitric oxide production activator in endothelial cells.

Měrná jednotka: 1 * 1 mg

New Product Akce

Dodavatel: ENZO LIFE SCIENCES

Popis: The Akt (PKB) family of protein kinases are serine/threonine kinases, with three mammalian family members identified (Akt1, Akt2, Akt3). Akt is a well-characterized member of PI3 kinase-mediated signaling pathways, regulating cell growth, apoptosis, glycogen synthesis, and other cellular responses through its phosphorylation of downstream substrates. Akt activation is triggered by binding of phospholipid and phosphorylation at two key residues: Thr308 by PDK1, and Ser473 by PDK2, now identified as mTOR. Deregulation of Akt signaling has been associated with cancer, diabetes, and schizophrenia. Akt1 is the cellular homologue of the murine thymoma retroviral oncogene v-akt, and its role in anti-apoptotic and pro-mitotic pathways have made Akt a molecular target for anti-cancer therapeutic intervention. Akt activation inhibits apoptosis by phosphorylating the Bcl-2 related protein Bad, and increases p53 degradation by phosphorylating mdm2. Mitotic substrates of Akt include GSK-3β, p21CIP1, and p27KIP1, cell cycle inhibitors negatively regulated by Akt phosphorylation. Akt has been shown to mediate angiogenesis through regulation of thrombospondins, which may cooperate with pro-mitotic and anti-apoptotic functions of Akt to promote tumorigenesis.

New Product

Katalogové číslo: (ENZOADI905773100)

Dodavatel: ENZO LIFE SCIENCES

Popis: The Akt (PKB) family of protein kinases are serine/threonine kinases, with three mammalian family members identified to date (Akt1, Akt2, Akt3). Akt is a well-characterized member of PI3 kinase-mediated signaling pathways, regulating cell growth, apoptosis, glycogen synthesis, and other cellular responses through its phosphorylation of downstream substrates. Akt activation is triggered by binding of phospholipid and phosphorylation at two key residues: Thr308 by PDK1, and Ser473 by PDK2, now identified as mTOR. Deregulation of Akt signaling has been associated with cancer, diabetes, and schizophrenia. Akt1 is the cellular homologue of the murine thymoma retroviral oncogene v-akt, and its role in anti-apoptotic and pro-mitotic pathways have made Akt a molecular target for anti-cancer therapeutic intervention. Akt activation inhibits apoptosis by phosphorylating the Bcl-2 related protein Bad, and increases p53 degradation by phosphorylating mdm2. Mitotic substrates of Akt include GSK-3β, p21CIP1, and p27KIP1, cell cycle inhibitors negatively regulated by Akt phosphorylation. Akt has been shown to mediate angiogenesis through regulation of thrombospondins, which may cooperate with pro-mitotic and anti-apoptotic functions of Akt to promote tumorigenesis.

Měrná jednotka: 1 * 100 µG

New Product Akce

Katalogové číslo: (J64554.MA)

Dodavatel: Thermo Scientific

Popis: A cell-permeable, potent, and selective inhibitor of GSK-3beta.

Měrná jednotka: 1 * 10 mg

Bezpečnostní list Akce

Dodavatel: ENZO LIFE SCIENCES

Popis: Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

New Product

Katalogové číslo: (ENZOALX350312M025)

Dodavatel: ENZO LIFE SCIENCES

Popis: Lignan derivative, which shows antitumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic and cytotoxic properties against Hep62 cells.  Antagonist for platelet activating factor and Ca²⁺. Blocks the activation of Akt (protein kinase B; PKB) induced by glucose starvation.

Měrná jednotka: 1 * 25 mg

New Product Akce

Katalogové číslo: (ENZOADI905643100)

Dodavatel: ENZO LIFE SCIENCES

Popis: Insulin-like growth factor-I (IGF-I) is a polypeptide hormone similar in structure to insulin. It is involved in regulation of neuronal growth and development in the central and peripheral nervous system. IGF-1 is a potent inhibitor of apoptosis in neurons, and activates the Akt signaling pathway via the IGF-1R and Insulin receptors. The IGF-1R acts as a receptor for IGF-1 and the related IGF-2, and is subject to autophosphorylation on multiple tyrosine residues that regulate receptor activation and assembly of signal transduction complexes.

Měrná jednotka: 1 * 100 µG

New Product Akce

Dodavatel: ENZO LIFE SCIENCES

Popis: Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.

New Product

Katalogové číslo: (BOSSBS-1324R-CY3)

Dodavatel: Bioss

Popis: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:1679162, PubMed:13864, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

Měrná jednotka: 1 * 100 µl

Akce