Hledali jste: 521-1750

Dodavatel: VWR Collection

Popis: Kompaktní centrifuga Micro Star 30R s chlazením je hospodárná, univerzální a snadno obsluhovatelná kombinovaná odstředivka, která v sobě spojuje funkce vysokorychlostní mikrocentrifugy a víceúčelové centrifugy. Tato centrifuga s tichým a plynulým chodem pojme rotory pro mikrozkumavky (24 × 1,5/2,0 ml), mikrotitrační destičky a kónické zkumavky o objemu 15/50 ml, ale i 16místný rotor pro zkumavky o objemu 5 ml a rotor s výkyvnými držáky na 6 krevních zkumavek. Ideální pro použití v přírodovědných, biotechnologických a klinických laboratořích.

Akce

Katalogové číslo: (BOSSBS-4708R-A750)

Dodavatel: Bioss

Popis: Alpha 1 Fetoprotein is a major plasma protein produced by the yolk sac and the liver during foetal life. Alpha fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the foetal counterpart of serum albumin, and the alpha fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. Expression has been documented in human adrenal, liver, ovary, testis, and pancreas. ESTs have been isolated from normal human brain, liver/spleen, embryo and uterus tissue libraries.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: VWR Collection

Popis: Kompaktní ventilovaná centrifuga Micro Star 30 je hospodárná, univerzální a snadno obsluhovatelná kombinovaná odstředivka, která v sobě spojuje funkce vysokorychlostní mikrocentrifugy a víceúčelové centrifugy. Tato centrifuga s tichým a plynulým chodem pojme rotory pro mikrozkumavky (24 × 1,5/2,0 ml), mikrotitrační destičky a kónické zkumavky o objemu 15/50 ml, ale i 16místný rotor pro zkumavky o objemu 5 ml a rotor s výkyvnými držáky na 6 krevních zkumavek. Ideální pro použití v přírodovědných, biotechnologických a klinických laboratořích.

Akce

Katalogové číslo: (ANTIA314074-96)

Dodavatel: ANTIBODIES.COM

Popis: Human KLF5 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human KLF5 in serum, plasma, and other biological fluids.

Měrná jednotka: 1 * 96 Tests

New Product Akce

Katalogové číslo: (BOSSBS-3619R-A750)

Dodavatel: Bioss

Popis: Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-270 kDa) found in variety of tissues and cell types. It is localised at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterised by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localised at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-9747R-A750)

Dodavatel: Bioss

Popis: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD20A (ankyrin repeat domain-containing protein 20A) is an 823 amino acid protein that contains five ANK repeats. The gene encoding ANKRD20A maps to chromosome 9, which consists of about 145 million bases and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterised by harmful vascular defects, and familial dysautonomia are associated with chromosome 9. Also, chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukaemias.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11296R-A750)

Dodavatel: Bioss

Popis: 17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV. It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11903R-A750)

Dodavatel: Bioss

Popis: Nur77 (also designated NGFI-B), Nurr1 (Nur-related factor 1), and NOR-1 (neuron-derived orphan receptor 1) constitute the NGFI-B subfamily within the nuclear receptor superfamily. Ligands for these protein have not been identified, and, therefore, they are designated orphan nuclear receptors. Genes of the NGFI-B subfamily are classified as immediate-early genes, which are induced rapidly, but transiently, in response to a variety of stimuli. They have been implicated in cell proliferation, differentiation, and apoptosis. The human NOR-1 gene maps to chromosome 9q, and encodes a protein which is expressed in heart, skeletal muscle, thymus, and spleen as well as in brain, where it is developmentally regulated. There-fore, NOR-1 may be involved in regulating neural differentiation. The NOR-1 gene also undergoes chromosomal translocation with the EWS gene to produce a protein thought to affect pre-mRNA splicing.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: VWR Collection

Popis: Tyto univerzální centrifugy jsou ideální pro řadu běžných aplikací ve farmaceutickém a biotechnologickém průmyslu a také pro akademický výzkum. Nabízejí výjimečnou kapacitu a ergonomický design, usnadňující práci na stolním přístroji.

Dodavatel: Biosensis

Popis: Fluoro-Jade stain is a fluorochrome derived from fluorescein, and is commonly used in neuroscience disciplines to label degenerating neurons in ex vivo tissue of the central nervous system.

Bezpečnostní list

Katalogové číslo: (BSENTR-160-FJC)

Dodavatel: Biosensis

Popis: The causes and effects of neuronal degeneration are of major interest to a wide variety of neuroscientists. Paralleling this growing interest is an increasing number of methods applicable to the detection of neuronal degeneration. Fluoro-Jade C stains all degenerating neurons regardless of specific insult or mechanism of cell death. Fluoro-Jade C exhibits the greatest signal to background ratio, as well as the highest resolution. This translates to a stain of maximal contrast and affinity for degenerating neurons. This makes it ideal for localising not only degenerating nerve cell bodies but also distal dendrites, axons and terminals. The dye is highly resistant to fading and is compatible with virtually all histological processing and staining protocols.

Měrná jednotka: 1 * 30 mg

Akce

Katalogové číslo: (BSENTR-150-FJB)

Dodavatel: Biosensis

Popis: The causes and effects of neuronal degeneration are of major interest to a wide variety of neuroscientists. Paralleling this growing interest is an increasing number of methods applicable to the detection of neuronal degeneration. The fluorescent dye Fluoro-Jade® B (FJB), like its more purified brother Fluoro-Jade® C (FJC), is an anionic fluorescein derivative useful for the histological staining of neurons undergoing degeneration.

Měrná jednotka: 1 * 30 mg

Akce

Dodavatel: Beckman Coulter

Popis: The Optima AUC includes new features to improve the user experience from method setup to data recovery. Quick-turn absorbance and interference optics, paired with remote instrument setup and viewing, offer streamlined method setup and live data analysis. Importantly, the Optima AUC maintains compatibility with existing Beckman AUC rotors and accessories. Resolving similar components, such as viral particle capsids, can be challenging. However, the faster scan rate and improved radial resolution in the Optima AUC enable enhanced discrimination of such materials. Along with greater wavelength precision, these enhancements yield more reliable and consistent results.

Katalogové číslo: (BOSSBS-3585R-A750)

Dodavatel: Bioss

Popis: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-3585R-A680)

Dodavatel: Bioss

Popis: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

Měrná jednotka: 1 * 100 µl

Akce