Hledali jste: 5,8-Dioxaspiro[3.4]octane-2-methanol

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5,8-Dioxaspiro[3.4]octane-2-methanol

Dodavatel: Apollo Scientific

Popis: 5,8-Dioxaspiro[3.4]octane-2-methanol

5,8-Dioxaspiro[3.4]octan-2-ylmethanamine

Dodavatel: Apollo Scientific

Popis: 5,8-Dioxaspiro[3.4]octan-2-ylmethanamine

WYE-125132 ≥99% (by HPLC)

Dodavatel: ENZO LIFE SCIENCES

Popis: Highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Antiproliferative.

New Product

WYE-125132 ≥98%, crystalline solid

Dodavatel: Cayman Chemical

Popis: WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.