Hledali jste: 4-Nitrophenyl+palmitate

Katalogové číslo: (BOSSBS-6073R-A488)

Dodavatel: Bioss

Popis: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (O7381-1AMP)

Dodavatel: Merck

Popis: Palmitic acid methyl ester (C16:0) 11,0% Stearic acid methyl ester (C18:0) 3,0% Oleic acid methyl ester (C18:1<i>cis</i>-9) 80,0% Linoleic acid methyl ester (C18:2<i>cis</i>-912) 6,0%.

Měrná jednotka: 1 * 1 Ampoul

Akce

Katalogové číslo: (BOSSBS-20594R-A750)

Dodavatel: Bioss

Popis: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidised low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalised and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-20595R-A750)

Dodavatel: Bioss

Popis: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidised low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalised and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-20595R-A680)

Dodavatel: Bioss

Popis: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidised low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalised and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Apollo Scientific

Popis: 2-(4-Nitrophenyl)imidazole

Katalogové číslo: (BOSSBS-20594R-A680)

Dodavatel: Bioss

Popis: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidised low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalised and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (O7631-1AMP)

Dodavatel: Merck

Popis: Myristic acid methyl ester (C14:0) 2,0% Palmitic acid methyl ester (C16:0) 30,0% Palmitoleic acid methyl ester (C16:1<i>cis</i>-9) 3,0% Stearic acid methyl ester (C18:0) 14,0% Oleic acid methyl ester (C18:1<i>cis</i>-9) 41,0% Linoleic acid methyl ester (C18:2<i>cis</i>-912) 7,0% Linolenic acid methyl ester (C18:3<i>cis</i>-91215) 3,0%.

Měrná jednotka: 1 * 1 Ampoul

Akce

Katalogové číslo: (APOSOR470030-1G)

Dodavatel: Apollo Scientific

Popis: 1-(4-Nitrophenyl)cyclopentanecarbonitrile

Měrná jednotka: 1 * 1 g

Akce

Katalogové číslo: (PRSI92-096)

Dodavatel: ProSci Inc.

Popis: Acyl-Protein Thioesterase 2 is a cytoplasmic protein that belongs to the AB Hydrolase 2 family. LYPLA2 is a lysophospholipase and hydrolyses fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. LYPLA2 has hydrolase activity that converts Palmitoyl-protein to palmitate and protein. LYPLA2 regulates the multifunctional lysophospholipids by acting on biological membranes. LYPLA2 participates in Glycerophospholipid metabolism pathway, fatty acid metabolic process and lipid metabolic process.

Měrná jednotka: 1 * 50 µG

Akce

Dodavatel: Apollo Scientific

Popis: 4-Nitrophenyl chloroformate

Dodavatel: Apollo Scientific

Popis: (4-Nitrophenyl)-α-D-galactopyranoside

Dodavatel: Thermo Fisher Scientific

Popis: 2-Nitrophenyl selenocyanate 97%

Bezpečnostní list Certifikáty

Dodavatel: Apollo Scientific

Popis: 2-(4-Nitrophenyl)acetohydrazide

Katalogové číslo: (APOSOR470196-1G)

Dodavatel: Apollo Scientific

Popis: 2-(2-Nitrophenyl)imidazole

Měrná jednotka: 1 * 1 g

Akce

Katalogové číslo: (APOSOR1252-5G)

Dodavatel: Apollo Scientific

Popis: 5-(3-Nitrophenyl)oxazole

Měrná jednotka: 1 * 5 g

Akce