Hledali jste: ENZO LIFE SCIENCES

Dodavatel: ENZO LIFE SCIENCES

Popis: Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

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Dodavatel: ENZO LIFE SCIENCES

Popis: DnaK possesses an autophosphorylation activity and a weak 5-nucleotidase activity, cleaving the 5 phosphate groups from both ribose and deoxyribose nucleotides. The role of DnaK in ATP-dependent protein-protein interactions has been extended to normal E. coli physiology, where, like eukaryotic Hsp70 homologs, it is thought to participate in the assembly/disassembly of protein complexes.

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Dodavatel: ENZO LIFE SCIENCES

Popis: Produced in <i>E. coli</i>.

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Dodavatel: ENZO LIFE SCIENCES

Popis: CD40 is a 45-50 kDa type I membrane protein and a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 is also known as pb50 or CDW40.  CD40 is expressed primarily by professional antigen-presenting cells and it is also expressed on non-immune cell types. The CD40 expressed by professional antigen-presenting cells plays a critical role in co-stimulation and antigen-presenting cell activation in T cell-dependent immune responses. Signals generated through CD40 in B cells are anti-apoptotic. These signals are also required for T cell-dependent B cell activation and proliferation, isotype switching, up-regulation of costimulatory receptors, germinal center formation and memory generation. CD40 signal transduction is initiated by binding trimeric CD40 ligand (CD40L) which is found on the surface of activated T cells.  CD40 engages several signalling pathways in B cells and these include NF-kB, the mitogen-activated protein kinases p38 and c-Jun N-terminal kinase. The 62 amino acid cytoplasmic domain (CD40c) of CD40 contains two linear TNF-receptor associated factor (TRAF) binding domains. The membrane proximal site of CD40c binds TRAF6 and the membrane distal site binds TRAF1, 2 and 3. CD40c is thought to mediate the CD40-dependant signalling pathways by recruitment of TRAF to this multimerized domain. CD40 ligation has also been shown to stimulate iNOS expression, and therefore NO production, by activating NF-kB in IFN-g treated microglial cells. NO derived from microglia has been implicated in the damage of myelin-producing oligodendrocytes in demyelinating disorders like multiple sclerosis (MS) and neuronal death during Alzheimer’s disease and brain trauma. Increased CD40-CD40 ligation has been implicated in the pathogenesis of several autoimmune inflammatory diseases, such as MS, arthritis and insulin-dependant diabetes.

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Katalogové číslo: (ENZOADICSA836E)

Dodavatel: ENZO LIFE SCIENCES

Popis: APRIL (A proliferation-inducing ligand) is a member of the TNF family. APRIL stimulates B- and T-cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death.

Měrná jednotka: 1 * 100 µG

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Katalogové číslo: (ENZOADIEKS715)

Dodavatel: ENZO LIFE SCIENCES

Popis: Only commercially available kit specifically validated and sensitive enough to quantify HSP70 (HSP72) in serum and plasma samples.

Měrná jednotka: 1 * 1 KIT

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Katalogové číslo: (ENZOADIEKS725A)

Dodavatel: ENZO LIFE SCIENCES

Popis: The HSP70B' EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in < 4.5 hours. Absorbance is read at 450 nm. Save time, money, and precious sample with fully quantitative results and increased sensitivity compared to Western blot analysis.Only commercially available ELISA kit for ultra-sensitive HSP70B' detection in cell lysates, serum, and tissue.

Měrná jednotka: 1 * 1 KIT

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Katalogové číslo: (ENZOADIEKS390A)

Dodavatel: ENZO LIFE SCIENCES

Popis: The PKA Kinase activity kit is an efficient assay that utilizes little sample volume. This kit gives you the ability to an end-point or kinetic assay read-out in a convenient 96-well plate based assay and offers easy sample handling protocols. The assay also offers a high signal to background ratio.

Měrná jednotka: 1 * 1 KIT

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Dodavatel: ENZO LIFE SCIENCES

Popis: Produced in <i>E.coli</i>.

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Dodavatel: ENZO LIFE SCIENCES

Popis: Fluorogenic substrate for furin/SPC1/PACE/PCSK3 and other subtilisin/kexin-like proprotein convertases such as Kex2, SPC2/PC2/PCSK2, SPC3/PCSK1, PACE4/SPC4/PCSK6, SPC5/PC4/PCSK4, SPC6/PC5/PC6/PCSK5, and SPC7/LPC/PC7/PC8/PCSK7. Can be used on live cells. Ex: 340-360 nm, Em: 440-460 nm.

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Katalogové číslo: (ENZOALX260048M001)

Dodavatel: ENZO LIFE SCIENCES

Popis: Caspase substrate

Měrná jednotka: 1 * 1 mg

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Dodavatel: ENZO LIFE SCIENCES

Popis: Irreversible, cell permeable broad-spectrum caspase inhibitor.

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Dodavatel: ENZO LIFE SCIENCES

Popis: Caspase and granzyme substrate

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Dodavatel: ENZO LIFE SCIENCES

Popis: Inhibitor of caspase-1 and -4

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Dodavatel: ENZO LIFE SCIENCES

Popis: Inhibitor of caspase-1 and -4

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Katalogové číslo: (ENZOALX210956C100)

Dodavatel: ENZO LIFE SCIENCES

Popis: Viperin has been identified as a human cytomegalovirus and IFN-γ inducible protein. Its expression is activated by both TLR3-dependent and RIG-I-dependent pathways. Viperin inhibits influenza A virus release of infected cells by altering plasma membrane fluidity and the formation of lipid rafts. It acts on the lipid rafts by decreasing the activity of the enzyme farnesyl diphosphate synthase (FPPS) which is essential for isoprenoid biosynthesis.

Měrná jednotka: 1 * 100 µG

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