Hledali jste: polycln

Katalogové číslo: (BOSSBS-12564R)

Dodavatel: Bioss

Popis: The protease enzyme Lethal Factor (LF) is one of the three proteins (LF, EF & PA) composing the anthrax toxin produced by Bacillus anthracis, a bacteria which can infect many mammalian species and that may be fatal. LF is not toxic by itself, but when associated with Protective Antigen (PA), can then gain entry to cells. Once inside the cell, LF then cleaves the N terminal of most dual specificity mitogen activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N terminal proline rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LF intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11861R)

Dodavatel: Bioss

Popis: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11874R)

Dodavatel: Bioss

Popis: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T cells signaling pathway.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI138430)

Dodavatel: US Biological

Popis: Anti-Thymocyte Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 20 mg

Akce

Katalogové číslo: (USBI044514)

Dodavatel: US Biological

Popis: Anti-ANGPTL3 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µG

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Katalogové číslo: (USBI125526)

Dodavatel: US Biological

Popis: Anti-CYB5R2 Mouse Polyclonal Antibody

Měrná jednotka: 1 * 50 µG

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Katalogové číslo: (USBI125524)

Dodavatel: US Biological

Popis: Anti-CYB5R1 Mouse Polyclonal Antibody

Měrná jednotka: 1 * 50 µG

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Katalogové číslo: (USBI131032)

Dodavatel: US Biological

Popis: Anti-PDCD2 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS6553)

Dodavatel: Bioworld Technology

Popis: Recombinant full length Human CD59.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS6126)

Dodavatel: Bioworld Technology

Popis: Recombinant full length Human DEFB132.

Měrná jednotka: 1 * 100 µG

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Katalogové číslo: (BWRLBS6533)

Dodavatel: Bioworld Technology

Popis: Recombinant full length Human BDNF.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (USBI123471)

Dodavatel: US Biological

Popis: Anti-ARG1 Mouse Polyclonal Antibody

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (USBI123474)

Dodavatel: US Biological

Popis: Anti-ARG2 Mouse Polyclonal Antibody

Měrná jednotka: 1 * 50 µG

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Katalogové číslo: (USBI038391)

Dodavatel: US Biological

Popis: Anti-METTL7B Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 200 µl

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Katalogové číslo: (USBI126724)

Dodavatel: US Biological

Popis: Anti-FCN1 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µG

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Katalogové číslo: (USBI136763)

Dodavatel: US Biological

Popis: Anti-CALR Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 50 µl

Akce