Hledali jste: lad1

Katalogové číslo: (BOSSBS-1302R-FITC)

Dodavatel: Bioss

Popis: Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L glutamate to g-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. GAD has a restricted tissue distribution. It is highly expressed in the cytoplasm of GABAergic neurons in the central nervous system (CNS) and pancreatic beta cells. It is also present in other non-neuronal tissues such as testis, oviduct and ovary. GAD is also transiently expressed in non-GABAergic cells of the embryonic and adult nervous system, suggesting its involvement in development and plasticity. GAD exists as two isoforms, GAD65 and GAD67 (molecular masses of 65 and 67 kD, respectively) that are encoded by two different genes. GAD65 is an ampiphilic, membraneanchored protein, (585 amino acid residues) and is encoded on human chromosome 10. GAD67 is a cytoplasmic protein (594 amino acid residues) and is encoded on chromosome 2. There is 64% amino acid identity between the two isoforms, with the highest diversity located at the N terminus, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. The two isoforms appear to have distinct intraneuronal distribution in the brain. GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS), IDDM is an autoimmune disease that results from T cell mediated destruction of pancreatic insulin-secreting beta cells. Islet-reactive T cells and primarily to GAD65 (also named beta cell autoantigen) can be detected in peripheral blood of 80% of recent-onset IDD patients and in pre-diabetic high-risk subjects before onset of clinical symptoms. This suggests that GAD may be an important marker in the early stages of the disease.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI040791-AP)

Dodavatel: US Biological

Popis: Anti-RAD1 Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (ABCAAB195897-100)

Dodavatel: Abcam

Popis: Anti-KDM1/LSD1 Rabbit Monoclonal Antibody [clone: EPR6825] (HRP)

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Portwest

Popis: The unique fabric technology locks in the body's warmth to create a thermal barrier for optimum wearer comfort.

Katalogové číslo: (ANTIA95533-100)

Dodavatel: ANTIBODIES.COM

Popis: Rabbit polyclonal antibody to GAD1 + GAD2 for WB, IHC and ELISA with samples derived from Human and Mouse.

Měrná jednotka: 1 * 100 µG

New Product Akce

Katalogové číslo: (USBIC2415-18K)

Dodavatel: US Biological

Popis: Anti-SELL Mouse Monoclonal Antibody [clone: LAM1-116]

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (USBI035670-FITC)

Dodavatel: US Biological

Popis: Anti-FLAD1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (BOSSBS-1595R-A555)

Dodavatel: Bioss

Popis: spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators. Like other spindle checkpoint mutants, MAD1 loss-of-function mutants are sensitive to benomyl and cannot delay cell division in response to spindle depolymerization. Mad1p becomes hyperphosphorylated upon spindle depolymerization.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-6800R-A350)

Dodavatel: Bioss

Popis: Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-6800R-A488)

Dodavatel: Bioss

Popis: Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-6800R-A647)

Dodavatel: Bioss

Popis: Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-6800R-A680)

Dodavatel: Bioss

Popis: Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Biorbyt

Popis: Anti-GAD1 Rabbit Polyclonal Antibody

Katalogové číslo: (ORIGTA308831)

Dodavatel: OriGene

Popis: Anti-RAD1 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (PRSI58-203)

Dodavatel: ProSci Inc.

Popis: For WB starting dilution is: 1:1000.

Měrná jednotka: 1 * 400 µl

New Product Akce

Katalogové číslo: (ABNOPAB12919)

Dodavatel: Abnova

Popis: Rabbit polyclonal antibody raised against synthetic peptide of DAD1.

Měrná jednotka: 1 * 100 µG

Akce