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Anti-Histone H3, dimethyl Rabbit monoclonal antibody [clone: 11C1040]

Katalogové číslo: (USBIH5110-12W)

Dodavatel: US Biological

Popis: Anti-Histone H3, dimethyl Rabbit Monoclonal Antibody [clone: 11C1040]

Měrná jednotka: 1 * 100 µl

Akce

N/A Each

Anti-histone H2A Rabbit Polyclonal Antibody

Katalogové číslo: (CAYM13535-1)

Dodavatel: Cayman Chemical

Popis: Anti-histone H2A Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 1 KS

Akce

N/A Each

Anti-Centromeric Histone H3-like Protein-2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Katalogové číslo: (BOSSBS-0483R-A750)

Dodavatel: Bioss

Popis: Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognise specific histone modifications (the 'histone code' hypothesis). Trimethylation of histone H3 on Lys9 (H3K9me3) is one of the most highly studied epigenetic marks. H3K9me3 functions in the repression of euchromatic genes, and in epigenetic control of heterochromatin assembly, most likely via acting as a recognition motif for the binding of chromatin-associated proteins, such as Swi6 or HP1Alpha/Beta. The enzymes responsible for H3K9me3 formation are SUV39H1 and SUV39H2.

Měrná jednotka: 1 * 100 µl

Akce

N/A Each

Anti-Histone H2A.Z Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Katalogové číslo: (BOSSBS-8154R-A750)

Dodavatel: Bioss

Popis: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

Měrná jednotka: 1 * 100 µl

Akce

N/A Each

Anti-Centromeric histone H3-like Protein-2 Rabbit Polyclonal Antibody (Cy5®)

Katalogové číslo: (BOSSBS-0621R-CY5)

Dodavatel: Bioss

Popis: Centromeric histone H3-like protein-2

Měrná jednotka: 1 * 100 µl

Akce

N/A Each

Anti-Histone H2AX Mouse Monoclonal Antibody

Dodavatel: ENZO LIFE SCIENCES

Popis: The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The core histones form an octamer, which is made up of one H3-H4 tetramer and two H2A-H2B dimers. The N-terminal tail of core histones undergoes different post-transcriptional modifications including acetylation, phosphorylation, methylation and ubiquitination. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression.

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