Hledali jste: SMCC+(N-Succinimidyl+4-(N-Maleimidomethyl)cyclohexanecarboxylate)

Katalogové číslo: (BC20)

Dodavatel: G-Biosciences

Popis: Succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate Heterobifunctional Cross Linkers.

Měrná jednotka: 1 * 100 mg

Akce

Dodavatel: Apollo Scientific

Popis: Primary amine and Sulphhydryl reactive, Enzyme antibody conjugation.

Katalogové číslo: (PIERA35394)

Dodavatel: Thermo Fisher Scientific

Popis: Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.

Měrná jednotka: 1 * 10 mg

Akce

Dodavatel: AAT BIOQUEST INC

Popis: SMCC is a non-cleavable and membrane permeable crosslinker with a spacer arm of 8.3 Å. It contains an amine-reactive succinimidyl ester (SE) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7 to 9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5 to 7.5 to form stable thioether bonds. The SE group of SMCC is reacted with lysine residues on the carrier protein, converting them to reactive maleimides. SMCC is a reagent that is widely used for generating stable maleimide-activated carrier proteins that can spontaneously react with sulfhydryls. Alternatively these relatively stable maleimide-activated intermediates may be lyophilized and stored for later conjugation to a hapten.

New Product

Katalogové číslo: (PIER22360)

Dodavatel: Thermo Fisher Scientific

Popis: Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.

Měrná jednotka: 1 * 50 mg

Bezpečnostní list Certifikáty Akce

Katalogové číslo: (BC23)

Dodavatel: G-Biosciences

Popis: Ideal for enzyme-antibody crosslinking.

Měrná jednotka: 1 * 100 mg

Akce

Dodavatel: Thermo Scientific

Popis: Sulpho-SMCC (3-Sulpho-N-succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt) ≥97%

Bezpečnostní list Certifikáty

Katalogové číslo: (APOSBICL207-100MG)

Dodavatel: Apollo Scientific

Popis: Primary amine & Sulphhydryl reactiveEnzyme-antibody conjugation -Stable maleimide groupRef: Hushida, S. et al (1984) J.Applied Biochem. 56,56-63

Měrná jednotka: 1 * 100 mg

Akce

Katalogové číslo: (PIERA39268)

Dodavatel: Thermo Fisher Scientific

Popis: Thermo Scientific Pierce Sulfo-SMCC, No-Weigh Format is a water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 angstroms).

Měrná jednotka: 1 * 20 mg

Akce

Dodavatel: Thermo Fisher Scientific

Popis: Thermo Scientific Pierce Premium Grade Sulfo-SMCC is our highest quality formulation of amine-to-sulfhydryl crosslinker, specially characterized for applications where product integrity and risk minimization are paramount.

Katalogové číslo: (AATB4503)

Dodavatel: AAT BIOQUEST INC

Popis: Compared to SMCC and sulfo-SMCC, SMCC Plus has enhanced water solubility and crosslinking efficiency.

Měrná jednotka: 1 * 5 mg

New Product Akce

Katalogové číslo: (786-082)

Dodavatel: G-Biosciences

Popis: Ideal for enzyme-antibody crosslinking.

Měrná jednotka: 1 * 8 KS

Akce

Dodavatel: Thermo Fisher Scientific

Popis: Thermo Scientific Pierce Sulfo-SMCC, No-Weigh Format is a water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 angstroms).

Katalogové číslo: (PIER22362)

Dodavatel: Thermo Fisher Scientific

Popis: Thermo Scientific Pierce LC-SMCC is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long cyclohexane-stabilized spacer arm (16.2 angstroms).

Měrná jednotka: 1 * 50 mg

Akce

Dodavatel: AAT BIOQUEST INC

Popis: Sulfo-SMCC is the water-soluble version of SMCC.

New Product

Katalogové číslo: (SIAL803383-50MG)

Dodavatel: Merck

Popis: LC-SMCC is a heterobifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while the maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values greater than 7.5. For these reasons, conjugation experiments involving this type of heterobifunctional crosslinker are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction

Měrná jednotka: 1 * 50 mg

Akce