Hledali jste: Protoporphyrin+IX

Katalogové číslo: (BOSSBS-9521R-A555)

Dodavatel: Bioss

Popis: Ferrochelatase catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway, and is localised in the mitochondrion. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme biosynthetic pathway (also called porphyrin pathway). They are broadly classified as hepatic porphyrias or erythropoietic porphyrias, based on the site of the overproduction and mainly accumulation of the porphyrins (or their chemical precursors). They manifest with either skin problems, or neurological complications, or occasionally both.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-9521R-CY7)

Dodavatel: Bioss

Popis: Ferrochelatase catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway, and is localised in the mitochondrion. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme biosynthetic pathway (also called porphyrin pathway). They are broadly classified as hepatic porphyrias or erythropoietic porphyrias, based on the site of the overproduction and mainly accumulation of the porphyrins (or their chemical precursors). They manifest with either skin problems, or neurological complications, or occasionally both.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-9521R-FITC)

Dodavatel: Bioss

Popis: Ferrochelatase catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway, and is localised in the mitochondrion. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme biosynthetic pathway (also called porphyrin pathway). They are broadly classified as hepatic porphyrias or erythropoietic porphyrias, based on the site of the overproduction and mainly accumulation of the porphyrins (or their chemical precursors). They manifest with either skin problems, or neurological complications, or occasionally both.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-9521R-HRP)

Dodavatel: Bioss

Popis: Ferrochelatase catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway, and is localised in the mitochondrion. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme biosynthetic pathway (also called porphyrin pathway). They are broadly classified as hepatic porphyrias or erythropoietic porphyrias, based on the site of the overproduction and mainly accumulation of the porphyrins (or their chemical precursors). They manifest with either skin problems, or neurological complications, or occasionally both.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (PRSI29-655)

Dodavatel: ProSci Inc.

Popis: Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria.Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene.Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSI29-620)

Dodavatel: ProSci Inc.

Popis: Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria.Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene.

Měrná jednotka: 1 * 100 µG

Akce

Dodavatel: MP Biomedicals

Popis: δ-Aminolevulinic acid hydrochloride is the universal precursor of tetrapyrroles, such as chlorophyll and heme.
δ-Aminolevulinic acid hydrochloride is used in the synthesis of hemes, vitamin B12 and bacteriochlorophyll. It is used in porphyrin biosynthesis studies. It enhances chlorophyll formation and may be used as a photodynamic herbicide is a precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme.
5-Aminolevulinic acid (5-ALA) is an intermediate in heme biosynthesis and is being studied as an inducing reagent for protoporphyrin IX (PPIX) dependent fluorescence diagnosis of metastatic lymph nodes. 5-ALA is used for photodynamic therapy of diseases such as Paget’s disease and HPV infection-associated cervical condylomata acuminata.

Katalogové číslo: (ENZOADIOSA400E)

Dodavatel: ENZO LIFE SCIENCES

Popis: Cleavage of heme b (Fe-protoporphyrin IX) at the a-methene carbon bridge to form the open tetrapyrrole, biliverdin IXa and carbon monoxide (CO) is catalyzed by heme oxygenase (HO) isozymes HO-1 and HO-2 (heme hydrogen-donor: oxygen oxidoreductase; EC 1.14.99.3). In mammalian species, biliverdin reductase (BVR; bilirubin: NAD(P)+ oxidoreductase; EC 1.3.1.24) converts the open tetrapyrrole to bilirubin. This pathway represents the only efficient way of making bilirubin and thereby deterring activation of oxygen by the heme molecule. HO-1 belongs to the heat shock protein family (Hsp32), while HO-2 takes a constitutive form expressed at exceedingly high levels in the brain and testes. The end products of the heme degradation process carry out important physiological activities. CO may act as a messenger in the brain and systemic organs stimulating cGMP-production through interactions with the heme-dependent form of guanylate cyclase. Bile pigments display potent antioxidant activity as well as effective antiviral activity against HIV and herpes virus. BVR is unique among all enzymes characterized to date in having two pH optima (6.8 and 8.7), using a different cofactor at each pH range (NADH at pH 7.0 and NADPH at pH 8.7). The enzyme displays pI and molecular mass microheterogeneity, apparently a result of post translational modifications. In rat, the enzyme also shows a tissue specific developmental pattern. BVR is not inactivated by heat shock, and its preexisting message is not sequestered from translation subsequent to thermal stress. Furthermore, reductase preserves microheterogeneity under thermal stress. BVR expression occurs not only in cells and brain regions that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. Rat cDNA for BVR has been isolated and characterized. The deduced protein contains 3 cysteine residues (Cys73, Cys281, and Cys290) involved in cofactor and substrate binding. Human BVR consists of a substantially longer polypeptide than the rat enzyme (41-42 kDa vs. 33 kDa), but also is dual cofactor and dual pH dependent, requires free SH groups for activity, and displays pI and molecular mass microheterogeneity. The human and rat BVR share some antigenic epitopes and show immunochemical cross reactivity.

Měrná jednotka: 1 * 100 µG

Akce

Dodavatel: Thermo Fisher Scientific

Popis: Mesoporphyrin IX dihydrochloride ≥97%

Bezpečnostní list Certifikáty

Katalogové číslo: (ENZOBMLEI2830001)

Dodavatel: ENZO LIFE SCIENCES

Popis: Cell-permeable PKC inhibitor. Selective for PKC (IC50=10nM) over CaM kinase II (IC50=17µM) and PKA (IC50=0.9µM). Induces apoptosis in various cell lines.

Měrná jednotka: 1 * 1 mg

Akce

Katalogové číslo: (APOSBITP2139-1MG)

Dodavatel: Apollo Scientific

Popis: Anti-Factor-IX Mouse Antibody

Měrná jednotka: 1 * 1 mg

Akce

Katalogové číslo: (BWRLBS9246)

Dodavatel: Bioworld Technology

Popis: Synthetic peptide, corresponding to amino acids 971-1020 of Human A Cyclase IX.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS2975)

Dodavatel: Bioworld Technology

Popis: Synthetic peptide, corresponding to amino acids 50-104 of Human CA IX.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (ABCAAB175075-100)

Dodavatel: Abcam

Popis: Anti-Factor IX/PTC Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (AGRIAS07228)

Dodavatel: Agrisera

Popis: Anti-HemH Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (ABCAAB236279-100)

Dodavatel: Abcam

Popis: Anti-Factor IX/PTC Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µG

Akce