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Image Unavailable-PRSI91-089

Human Recombinant BID (from E. coli)

Katalogové číslo: (PRSI91-089)
Dodavatel: ProSci Inc.
Popis: BH3-Interacting Domain Death Agonist (BID) is a member of the Bcl-2 protein family which regulates outer mitochondrial membrane permeability. BID is a pro-apoptotic member that causes cytochrome c to be released from the mitochondria intermembrane space into the cytosol. Interaction of Bid with Bak causes altered mitochondrial membrane permeability. BID contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. It is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent, and also offer a new strategy for the treatment of acute renal failure associated with ischemia-reperfusion. BID receives direct inputs from a key regulator of the cell cycle arrest/DNA repair machinery (ATM), and therefore is an excellent candidate to coordinate genotoxic stress responses and apoptotic cell death. BID is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Deletion of BID inhibits carcinogenesis in the liver, although this genetic alteration promotes tumorigenesis in the myeloid cells. This is likely related to the function of BID to promote cell cycle progression into S phase. BID could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint.
Měrná jednotka: 1 * 0,05 mg

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Image Unavailable-BOSSBS-7103R

Anti-THAP1 Rabbit Polyclonal Antibody

Katalogové číslo: (BOSSBS-7103R)
Dodavatel: Bioss
Popis: THAP1 contains a THAP domain, a zinc-dependent DNA-binding domain. It colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies and is a pro-apoptopic protein that potentiates both serum-withdrawal and TNF-induced apoptosis. It is a physiologic regulator of endothelial cell proliferation and cell-cycle progression, two essential processes for angiogenesis.
Měrná jednotka: 1 * 100 µl
Product Image-8181-96

Destičky k precipitaci proteinu J.T.Baker® Bakerbond®

Dodavatel: Avantor
Popis: Destičky k precipitaci proteinu J.T.Baker® Bakerbond® umožňují rychlé odstranění proteinů z biologických vzorků.

Image Unavailable-BOSSBS-13671R

Anti-TRAF6BP Rabbit Polyclonal Antibody

Katalogové číslo: (BOSSBS-13671R)
Dodavatel: Bioss
Popis: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Měrná jednotka: 1 * 100 µl
Product Image-MFLX43300-22

Flowline Switch-Pro Compact Level Controllers and Compact Junction Boxes

Dodavatel: Avantor Fluid Handling
Popis: Easily mounts to any sensor or fitting assembly.

Image Unavailable-BOSSBS-13671R-A350

Anti-TRAF6BP Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Katalogové číslo: (BOSSBS-13671R-A350)
Dodavatel: Bioss
Popis: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-13671R-CY5

Anti-TRAF6BP Rabbit Polyclonal Antibody (Cy5®)

Katalogové číslo: (BOSSBS-13671R-CY5)
Dodavatel: Bioss
Popis: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-1346R-A555

Anti-TRP73 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Katalogové číslo: (BOSSBS-1346R-A555)
Dodavatel: Bioss
Popis: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-10306R-CY7

Anti-TREM1 Rabbit Polyclonal Antibody (Cy7®)

Katalogové číslo: (BOSSBS-10306R-CY7)
Dodavatel: Bioss
Popis: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-10306R-CY3

Anti-TREM1 Rabbit Polyclonal Antibody (Cy3®)

Katalogové číslo: (BOSSBS-10306R-CY3)
Dodavatel: Bioss
Popis: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-7090R-CY3

Anti-CARD17 Rabbit Polyclonal Antibody (Cy3®)

Katalogové číslo: (BOSSBS-7090R-CY3)
Dodavatel: Bioss
Popis: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-13671R-A680

Anti-TAX1BP1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Katalogové číslo: (BOSSBS-13671R-A680)
Dodavatel: Bioss
Popis: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-13671R-CY7

Anti-TRAF6BP Rabbit Polyclonal Antibody (Cy7®)

Katalogové číslo: (BOSSBS-13671R-CY7)
Dodavatel: Bioss
Popis: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-7090R-CY5

Anti-CARD17 Rabbit Polyclonal Antibody (Cy5®)

Katalogové číslo: (BOSSBS-7090R-CY5)
Dodavatel: Bioss
Popis: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-7090R-CY7

Anti-CARD17 Rabbit Polyclonal Antibody (Cy7®)

Katalogové číslo: (BOSSBS-7090R-CY7)
Dodavatel: Bioss
Popis: Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
Měrná jednotka: 1 * 100 µl
Image Unavailable-SHBT500-03-1MG

Human Recombinant FLT-3 (CTGrade GMP) (from E. coli)

Dodavatel: Shenandoah Biotechnology
Popis: IL-6 is an important pro-inflammatory and anti-inflammatory cytokine expressed by T cells, macrophages, and muscle cells. Signals through a receptor complex containing two receptors, IL-6Rα and gp130. Plays an important function in promoting fever and can serve to stimulate an immune response to trauma.

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Cena na vyžádání
Omezené množství produktu na skladě. Zboží může být k dispozici v jiném skladě poblíž vašeho sídla. Přesvědčte se, že jste přihlášení na stránky, abyste mohli vidět dostupné položky na skladě. Pokud je stále zobrazeno call a potřebujete asistenci, volejte na číslo 321 570 321.
Omezené množství produktu na skladě. Zboží může být k dispozici v jiném skladě poblíž vašeho sídla. Přesvědčte se, že jste přihlášení na stránky, abyste mohli vidět dostupné položky na skladě. Pokud je stále zobrazeno call a potřebujete asistenci, volejte na číslo 321 570 321.
Daná chemikálie je regulována dle platné legislativy a bude vyžadováno vyplnění formuláře. Jeho včasným vyplněním uspíšíte dodání produktu.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Tento produkt je zablokován vaší organizací. Kontaktujte své nákupní oddělení pro více informací.
Původní produkt již není k dispozici. Zobrazen je náhradní produkt.
Tento produkt již není k dispozici. Podobné produkty můžete vyhledat pomocí VWR katalogových čísel nebo čísel dodavatele uvedených výše. Pokud potřebujete další asistenci, zavolejte na telefonní číslo zákaznického servisu VWR 321 570 321.
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