Hledali jste: PP1

Dodavatel: Apollo Scientific

Popis: PP1 free base ≥99%

Dodavatel: ENZO LIFE SCIENCES

Popis: Src kinase inhibitor

New Product

Katalogové číslo: (USBIP9107-20A)

Dodavatel: US Biological

Popis: Anti-PP1 gamma1 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BOSSBS-11666R)

Dodavatel: Bioss

Popis: Eukaryotic protein phosphorylation and dephosphorylation on serine and threonine residues regulates numerous cell functions, including division, homeostasis and apoptosis. A group of proteins that play a major role in this process are the serine/threonine protein phosphatases. Protein phosphatase (PP) holoenzyme is a trimeric complex that contains a regulatory subunit, a variable subunit and a catalytic subunit. Families of PP catalytic subunits include PP1, PP2A, PP2B, PP2C, PPX and PP5. Regulatory subunits include nuclear inhibitor of PP1 (NIPP1), PP1 nuclear targeting subunit (PNUTS), PP2A-A, PP2A-B, PP2A-B56, PP2A-C, PP2B-B and PR48. PNUTS, also designated CAT53 or FB19, is encoded by the gene PPP1R10. PNUTS acts as an inhibitor for the phosphatase activity of PP1 Alpha and PP1 Gamma. It is a nuclear protein primarily detected in nucleoplasmic bodies and within nucleoli. PNUTS expression levels are highest in brain, heart, lung, placenta, liver, kidney, pancreas and skeletal muscle.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11988R-CY7)

Dodavatel: Bioss

Popis: Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons; it localizes in the growth cone lamellipodia during neuronal development (1). Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1). Neurabin I recruits active PP1 via a PP1-docking sequence; mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2,3). Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4). Neurabin II localizes to neuronal dentritic spines, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5). Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5). Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5). Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4).

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: ENZO LIFE SCIENCES

Popis: Inhibitor of PP1 and PP2A

New Product

Katalogové číslo: (ENZOALX350431C010)

Dodavatel: ENZO LIFE SCIENCES

Popis: Inhibitor of PP1 and PP2A

Měrná jednotka: 1 * 10 µG

New Product Akce

Dodavatel: ENZO LIFE SCIENCES

Popis: Inhibitor of PP1 and PP2A

New Product

Dodavatel: ENZO LIFE SCIENCES

Popis: Inhibitor of PP1 and PP2A

New Product

Katalogové číslo: (BOSSBS-11988R-A555)

Dodavatel: Bioss

Popis: Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons; it localizes in the growth cone lamellipodia during neuronal development (1). Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1). Neurabin I recruits active PP1 via a PP1-docking sequence; mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2,3). Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4). Neurabin II localizes to neuronal dentritic spines, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5). Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5). Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5). Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11988R-CY5)

Dodavatel: Bioss

Popis: Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons; it localizes in the growth cone lamellipodia during neuronal development (1). Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1). Neurabin I recruits active PP1 via a PP1-docking sequence; mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2,3). Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4). Neurabin II localizes to neuronal dentritic spines, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5). Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5). Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5). Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11988R-A680)

Dodavatel: Bioss

Popis: Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons; it localizes in the growth cone lamellipodia during neuronal development. Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation. Neurabin I recruits active PP1 via a PP1-docking sequence; mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells. Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain. Neurabin II localizes to neuronal dentritic spines, which are the specialised protrusions from dendritic shafts that receive most of the excitatory input in the CNS. Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells. Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis. Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (APOSBIC1019-10UG)

Dodavatel: Apollo Scientific

Popis: PP1 inhibitor, PP2 inhibitor, serine/threonine phosphatatase inhibitor.

Měrná jednotka: 1 * 10 g

New Product Akce

Katalogové číslo: (BOSSBS-3658R-A750)

Dodavatel: Bioss

Popis: Inhibitor subunit of the major nuclear protein phosphatase 1 (PP1). It has RNA binding activity but does not cleave RNA and may target PP1 to RNA associated substrates. May also be involved in pre mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-3658R-FITC)

Dodavatel: Bioss

Popis: Inhibitor subunit of the major nuclear protein phosphatase 1 (PP1). It has RNA binding activity but does not cleave RNA and may target PP1 to RNA associated substrates. May also be involved in pre mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-3658R-A350)

Dodavatel: Bioss

Popis: Inhibitor subunit of the major nuclear protein phosphatase 1 (PP1). It has RNA binding activity but does not cleave RNA and may target PP1 to RNA associated substrates. May also be involved in pre mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.

Měrná jednotka: 1 * 100 µl

Akce