Hledali jste: N-ethylmaleimid+(NEM)

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Anti-CPLX1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Katalogové číslo: (BOSSBS-11341R-A350)

Dodavatel: Bioss

Popis: Complexin 1 and Complexin 2, also designated Synaphin 1 and Synaphin 2, contain an a-helical middle domain of approximately 58 amino acids. Complexin 1 and Complexin 2 are expressed in presynaptic terminals of inhibitory and excitatory hippocampal neurons, respectively, and in cytoplasmic pools during early stages of development. Complexins promote SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) precomplex formation by binding to synaxin with its a-helical domain. Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release and preceding vesicle fusion. Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process. Complexin 2 may play a role in LTP (long term potentiation) following tetanic stimulation. A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, an autosomal dominant neurodegenerative disorder. Changes in the neurotransmitter release might contribute to the motor, emotional and cognitive dysfunctions seen in these mice.

Měrná jednotka: 1 * 100 µl

Akce

N/A Each

Anti-CPLX1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Katalogové číslo: (BOSSBS-11341R-A750)

Dodavatel: Bioss

Měrná jednotka: 1 * 100 µl

Akce

N/A Each

Human recombinant Autophagy 4A (from E. coli)

Katalogové číslo: (PRSI92-103)

Dodavatel: ProSci Inc.

Popis: Cysteine Protease ATG4A (ATG4A) is a cytoplasmic protein that belongs to the peptidase C54 family. ATG4A is widely expressed in many tissues at a low level, but the highest expression is observed in skeletal muscle and brain. ATG4A is a cysteine protease required for autophagy; it cleaves the C-terminal part of MAP1LC3, GABARAPL2 or GABARAP. ATG4A is inhibited by N-ethylmaleimide. It is suggested that ATG4A has a significant role in suppressing various cancers.

Měrná jednotka: 1 * 50 µG

Akce

N/A Each

Human recombinant syntaxin 7 (from cells)

Katalogové číslo: (PRSI92-579)

Dodavatel: ProSci Inc.

Popis: Syntaxin 7 (STX7) is a member of a family of membrane-trafficking proteins named as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), and mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. Syntaxin-7 has been shown to be present in both late endosomes and lysosomes, and to be required for both homotypic late endosome fusion and heterotypic fusion with lysosomes. STX7 has been shown to interact with STX8, VPS18, Vesicle-associated membrane protein 8 and VPS11.

Měrná jednotka: 1 * 50 µG

Akce

N/A Each

Anti-VAMP7 Rabbit Polyclonal Antibody

Katalogové číslo: (BSBTPB10017)

Dodavatel: Boster Bio

Popis: Vesicle-associated membrane protein 7 (VAMP-7), also known as SYBL1, is a protein that in humans is encoded by the VAMP7 gene. This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide- sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.

Měrná jednotka: 1 * 100 µG

Akce

N/A Each

Anti-VAMP7 Rabbit Polyclonal Antibody

Katalogové číslo: (PRSI6929)

Dodavatel: ProSci Inc.

Popis: VAMP7 Antibody: VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.

Měrná jednotka: 1 * 100 µG

Akce

N/A Each

Human recombinant Autophagy 4C (from E. coli)

Katalogové číslo: (PRSI92-044)

Dodavatel: ProSci Inc.

Popis: Cysteine Protease ATG4C (ATG4C) belongs to the peptidase C54 family. It is required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form which is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. ATG4C is a cytoplasmic protein and high expressed in skeletal muscle, liver, testis and heart. ATG4C can be inhibited by N-ethylmaleimide.

Měrná jednotka: 1 * 50 µG

Akce

N/A Each

Anti-NSF Rabbit Polyclonal Antibody

Katalogové číslo: (PRSI50-183)

Dodavatel: ProSci Inc.

Popis: NSF (N-ethylmaleimide sensitive fusion protein) is a critical component of the SNARE (soluble NSF attachment protein receptors) protein complex that is involved in synaptic vesicle trafficking. Specifically, NSF has been found to be essential in membrane fusion. Furthermore, NSF has been recently demonstrated to bind other protein complexes such as AMPA receptor subunits (GluR2), GATE-16, LMA-1 and Rabs suggesting a more diverse role in the assembly of various protein complexes (Whiteheart et al., 2004).

Měrná jednotka: 1 * 100 µl

Akce

N/A Each

Anti-NAPA Rabbit Polyclonal Antibody

Katalogové číslo: (PRSI31-120)

Dodavatel: ProSci Inc.

Popis: The 'SNARE hypothesis' is a model explaining the process of docking and fusion of vesicles to their target membranes. According to this model, membrane proteins from the vesicle (v-SNAREs) and proteins from the target membrane (t-SNAREs) govern the specificity of vesicle targeting and docking through mutual recognition. Once the 2 classes of SNAREs bind to each other, they form a complex that recruits the general elements of the fusion apparatus, namely NSF (N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of membrane fusion, thereby forming the 20S fusion complex. Alpha- and gamma-SNAP are found in a wide range of tissues and act synergistically in intra-Golgi transport. The sequence of the predicted 295-amino acid human protein encoded by NAPA shares 37%, 60%, and 67% identity with the sequences of yeast, Drosophila, and squid alpha-SNAP, respectively.

Měrná jednotka: 1 * 100 µG

Akce

N/A Each

Služby pro zařízení

Dodavatel: AVANTOR SERVICES

Popis: Provedení IQ/OQ nechlazeného inkubátoru u zákazníka. Kvalifikační protokoly nejsou zahrnuty. Cestovní poplatky v ceně (bez nákladů na leteckou dopravu).