Hledali jste: Lázn\u011B+s+odnímatelným+ob\u011Bhovým+\u010Derpadlem

Dodavatel: VWR Collection

Popis: Vodní lázně s dvojitou stěnou, vnitřní stěna z nerezové oceli a vnější z ocelových plátů s povrchovou úpravou. Všechny lázně s výjimkou 2litrového modelu mají vypouštěcí kohout a mohou být využívány s vodou nebo kovovými kuličkami. Lázně od objemu 5 l mají program pro ohřev s kuličkami, který se spouští z hlavní nabídky. Součástí volitelného příslušenství je zátka do odpadu, která chrání před případným ucpáním kuličkou, která by mohla zapadnout do odpadu. Poznámka: Lázně jsou klasifikovány jako bezpečné Safety Class 1, což znamená, že mohou běžet bez dozoru, pokud v nich nejsou používány hořlavé kapaliny.

Katalogové číslo: (BWRLBS7184)

Dodavatel: Bioworld Technology

Popis: Recombinant full length Human Ob-R.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (ABCAAB129760-100)

Dodavatel: Abcam

Popis: Anti-OB Cadherin Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BOSSBS-0961M-HRP)

Dodavatel: Bioss

Popis: Leptin receptor (OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. An OB-R transcript encodes a soluble form of the receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist. Human OB-R encodes a 1 165 amino acid residue precursor protein with a 22 amino acid residue signal peptide, an 816 amino acid residue extracellular domain, a 21 amino acid residue transmembrane domain and a 303 amino acid residue cytoplasmic domain.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BWRLBS2684)

Dodavatel: Bioworld Technology

Popis: Synthetic peptide, corresponding to amino acids 430-480 of Human OB-cadherin.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BWRLBS3494)

Dodavatel: Bioworld Technology

Popis: Synthetic peptide, corresponding to amino acids N-terminus of Human Ob.

Měrná jednotka: 1 * 100 µG

Akce

Dodavatel: Cayman Chemical

Popis: Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions <italic>in vivo</italic>. Rosiglitazone is a prototypical TZD and has served as a reference compound for this class. Rosiglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC₅₀ values of approximately 30 nM and 100 nM, respectively. Rosiglitazone is active <italic>in vivo</italic> as an antidiabetic agent in the <italic>ob/ob</italic> mouse model, and has been used as an oral hypoglycemic agent in the treatment of Type II diabetes in humans for many years.

Katalogové číslo: (BWRLBS3460)

Dodavatel: Bioworld Technology

Popis: Synthetic peptide, corresponding to amino acids 650-700 of Human Ob-R.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BOSSBS-0961M)

Dodavatel: Bioss

Popis: Leptin receptor (OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. An OB-R transcript encodes a soluble form of the receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist. Human OB-R encodes a 1 165 amino acid residue precursor protein with a 22 amino acid residue signal peptide, an 816 amino acid residue extracellular domain, a 21 amino acid residue transmembrane domain and a 303 amino acid residue cytoplasmic domain.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Cayman Chemical

Popis: A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway. Cerulenin also leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.

Katalogové číslo: (BOSSBS-11536R-A350)

Dodavatel: Bioss

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11536R-A647)

Dodavatel: Bioss

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11536R)

Dodavatel: Bioss

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11536R-A680)

Dodavatel: Bioss

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice, mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population. In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss. The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr and Bardet-Biedl. A candidate for the tub gene has been described. A G - transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron. A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice. It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11536R-CY3)

Dodavatel: Bioss

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11536R-A488)

Dodavatel: Bioss

Popis: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr鰉 (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G芓 transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).

Měrná jednotka: 1 * 100 µl

Akce