Hledali jste: Chlorin+e6

Dodavatel: Apollo Scientific

Popis: Chlorin e6

Katalogové číslo: (ENZOBMLCA3020050)

Dodavatel: ENZO LIFE SCIENCES

Popis: Calmodulin inhibitor

Měrná jednotka: 1 * 50 mg

New Product Akce

Katalogové číslo: (BOSSBS-1719R)

Dodavatel: Bioss

Popis: Anti-HPV16 E6 + HPV18 E6 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11776R-A750)

Dodavatel: Bioss

Popis: E6-associating protein is a component of the ubiquitin-mediated proteolytic pathway, which selectively targets proteins for degradation by the 26S proteasome. Ubiquitin (Ub) is directly conjugated to protein substrates by the transfer of Ub from an E2 ubiquitin conjugating enzyme to the target protein. This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such as E6-AP. Several substrates of E6-AP have been identified and include the tumour suppressor protein p53 and the mammalian homolog of Rad23, HHR23A. Previous studies have indicated that E6-AP associates with the human papillomavirus E6 oncogene, which complexes with p53 and thereby potentiates E6-AP mediated ubiquitination of p53. Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, and, in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which is characterised by severe motor dysfunction and mental retardation.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-11776R-A680)

Dodavatel: Bioss

Popis: E6-associating protein is a component of the ubiquitin-mediated proteolytic pathway, which selectively targets proteins for degradation by the 26S proteasome. Ubiquitin (Ub) is directly conjugated to protein substrates by the transfer of Ub from an E2 ubiquitin conjugating enzyme to the target protein. This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such as E6-AP. Several substrates of E6-AP have been identified and include the tumour suppressor protein p53 and the mammalian homolog of Rad23, HHR23A. Previous studies have indicated that E6-AP associates with the human papillomavirus E6 oncogene, which complexes with p53 and thereby potentiates E6-AP mediated ubiquitination of p53. Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, and, in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which is characterised by severe motor dysfunction and mental retardation.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-1719R-CY5.5)

Dodavatel: Bioss

Popis: Transcriptional transactivator. Binds double-stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-1719R-A555)

Dodavatel: Bioss

Popis: Transcriptional transactivator. Binds double-stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-1719R-A350)

Dodavatel: Bioss

Popis: Transcriptional transactivator. Binds double-stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI126057)

Dodavatel: US Biological

Popis: Anti-DUSP14 Mouse Monoclonal Antibody [clone: 4B5-E6]

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (USBI124808)

Dodavatel: US Biological

Popis: Anti-CDKN1B Mouse Monoclonal Antibody [clone: 4B4-E6]

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (USBIP1001-10B)

Dodavatel: US Biological

Popis: Anti-CDKN1B Mouse Monoclonal Antibody [clone: 4B4-E6]

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (BOSSBS-0990R-CY3)

Dodavatel: Bioss

Popis: Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-0990R)

Dodavatel: Bioss

Popis: Anti-HPV16 E6 protein Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-0990R-CY5)

Dodavatel: Bioss

Popis: Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-0990R-CY5.5)

Dodavatel: Bioss

Popis: Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-1719R-A647)

Dodavatel: Bioss

Popis: Transcriptional transactivator. Binds double-stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.

Měrná jednotka: 1 * 100 µl

Akce