Hledali jste: (Z)-4-Hydroxytamoxifen

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(Z)-4-Hydroxytamoxifen ≥98%

Dodavatel: ENZO LIFE SCIENCES

Popis: Tamoxifen metabolite

New Product

(Z)-4-Hydroxytamoxifen 99%

Katalogové číslo: (469501000.)

Dodavatel: Thermo Scientific

Popis: (Z)-4-Hydroxytamoxifen 99%

Měrná jednotka: 1 * 100 mg

New Product Akce

N/A Each

4-Hydroxytamoxifen, (E) and (Z) isomers (50:50), analytical standard, Supelco®

Dodavatel: Merck

Popis: Organic Standard, 4-Hydroxytamoxifen, (E) and (Z) isomers (50:50)

4-Hydroxytamoxifen, (E) and (Z) isomers (50:50), analytical standard, Supelco®

Katalogové číslo: (94873-10MG)

Dodavatel: Merck

Popis: Organic Standard, 4-Hydroxytamoxifen, (E) and (Z) isomers (50:50)

Měrná jednotka: 1 * 10 mg

Akce

N/A Each

Popis: Protein kinase C inhibitor (IC50 = 50-200 µM depending on assay conditions in MCF-7 cells or IC50 = 100 µM in rat brain). The PKC inhibition is also dependent on the phosopholipid concentration. Also inhibits both calmodulin-dependent and calmodulin-independent Ca2+-, Mg2+-ATPase. Tamoxifen is a selective estrogen response modifier (SERM), anti-angiogenetic factor. It is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Tamoxifen has been used to facilitate the recombination of ect2flox allele in mouse organs. It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation
Tamoxifen is a Protein kinase C inhibitor. It induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.