Hledali jste: Tonbo Biosciences

Katalogové číslo: (35-8065-M002)

Dodavatel: Tonbo Biosciences

Popis: Goat anti-Mouse IgM (mu chain) - Affinity Pure, FITC Conjugate

Měrná jednotka: 1 * 2 mg

Akce

Katalogové číslo: (35-8068-M001)

Dodavatel: Tonbo Biosciences

Popis: Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/ bovine, goat, human, mouse or rat IgG or serum

Měrná jednotka: 1 * 1 mg

Akce

Katalogové číslo: (35-8066-M002)

Dodavatel: Tonbo Biosciences

Popis: Goat anti-Mouse IgM (mu chain) - Affinity Pure, FITC Conjugate, min x w/human IgG or serum proteins

Měrná jednotka: 1 * 2 mg

Akce

Katalogové číslo: (35-8077-M002)

Dodavatel: Tonbo Biosciences

Popis: Rabbit anti-Mouse IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/human serum proteins

Měrná jednotka: 1 * 2 mg

Akce

Dodavatel: Tonbo Biosciences

Popis: The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will compete for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.

Katalogové číslo: (22-8067-M001)

Dodavatel: Tonbo Biosciences

Popis: Goat anti-Rabbit IgG (H&L) - Affinity Pure, Alkaline Phosphatase Conjugate

Měrná jednotka: 1 * 1 mg

Akce

Katalogové číslo: (72-8097-M001)

Dodavatel: Tonbo Biosciences

Popis: Donkey anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate

Měrná jednotka: 1 * 1 mg

Akce

Katalogové číslo: (72-8104-M001)

Dodavatel: Tonbo Biosciences

Popis: Goat anti-Rat IgG (H&L) - Affinity Pure, HRP Conjugate

Měrná jednotka: 1 * 1 mg

Akce

Dodavatel: Tonbo Biosciences

Popis: The HI30 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.

Dodavatel: Tonbo Biosciences

Popis: The NOK-1 antibody reacts with human CD178 (Fas ligand) in both membrane bound and soluble forms. Fas ligand is a 40 kDa transmembrane glycoprotein, a member of the TNF family, and is expressed by activated T and NK cells, neutrophils, and monocytes. Interactions between CD178 (Fas ligand) and CD95 (Fas) induce a program of apoptosis and play a key role in immune regulation and homeostasis. The extracellular domain of human CD178 can be cleaved from the surface by matrix metalloproteinases (MMPs) resulting in a 26 kDa soluble protein.

Dodavatel: Tonbo Biosciences

Popis: The SK1 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

Dodavatel: Tonbo Biosciences

Popis: The SK7 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

Dodavatel: Tonbo Biosciences

Popis: The UCHT2 antibody is specific for human CD5, a 67 kD transmembrane glycoprotein, that is expressed on most thymocytes, mature T cells, and a subset of B cells. CD5 is involved in modulating antigen receptor signaling in both T and B cells and binds to CD72, expressed on B cells.

Dodavatel: Tonbo Biosciences

Popis: The RM134L antibody recognizes CD252, also known as OX-40 Ligand or CD134 Ligand, a member of the TNF superfamily that is present on the surface of antigen presenting cells and activated B lymphocytes. The OX-40 Ligand interacts with OX-40 (CD134) which is expressed primarily on activated T cells. This costimulatory interaction leads to increased proliferation and IL-2 production responses of activated T cells, and at the same time enhances proliferation and immunoglobulin secretion by activated B cells.

Dodavatel: Tonbo Biosciences

Popis: The RPA-T8 antibody is specific for the 32 to 34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

Dodavatel: Tonbo Biosciences

Popis: The SK7 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognise antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.