Hledali jste: u0007

Katalogové číslo: (25-4801-U100)

Dodavatel: Tonbo Biosciences

Popis: The BM8.1 antibody is specific for mouse F4/80 antigen, a 125 kDa transmembrane protein widely expressed by members of the mononuclear phagocyte system and considered to be a key marker for mature macrophage cells. F4/80 is differentially expressed during myeloid cell development, and may be regulated by certain cytokines within the tissue microenvironment. Other cell types shown to express this antigen include Langerhans cells, Kupffer cells and dendritic cell subsets. BM8.1 is widely used together with antibodies to CD115 (c-fms), CD11b and CD11c to identify myeloid / macrophage cells by flow cytometry.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (25-0031-U100)

Dodavatel: Tonbo Biosciences

Popis: The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The 145-2C11 antibody is a widely used phenotypic marker for mouse T cells. In addition, binding of 145-2C11 antibody to CD3e can induce cell activation. A recent publication of the crystal structure of a murine CD3e-mitogenic antibody complex provides further insight into the action of commonly used agonist antibodies (Fernandes, R.A. et al. 2012. J. Biol. Chem. 287: 13324-13335).

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (25-0621-U100)

Dodavatel: Tonbo Biosciences

Popis: The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte "rolling" on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin family of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research. The MEL-14 antibody may be used as a phenotypic marker for CD62L expression on a variety of immune cell types. Please note that CD62L (L-Selectin) itself is also referred to as MEL-14 in the literature.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (91-0000-U100)

Dodavatel: Tonbo Biosciences

Popis: The Mouse T Lymphocyte Subset backbone panel consists of 3 anti-mouse antibodies, each conjugated to a different fluorochrome. This panel can serve as a backbone for identifying major T cell subsets, and leaves room for additional drop-in markers, if desired. An APC version of this panel is available, where the anti-CD8a antibody is conjugated to APC. Hosts: Armenian Hamster, Rat

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (50-4732-U100)

Dodavatel: Tonbo Biosciences

Popis: The MPC-11 immunoglobulin is useful as an isotype-matched control. The MPC-11 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2b antibodies.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (40-4321-U100)

Dodavatel: Tonbo Biosciences

Popis: The 2A3 immunoglobulin is useful as an isotype-matched control. The 2A3 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2a antibodies.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (65-4714-U100)

Dodavatel: Tonbo Biosciences

Popis: PerCP-Cyanine5.5 Mouse IgG1 Isotype Control (MOPC-21)

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (60-1522-U100)

Dodavatel: Tonbo Biosciences

Popis: The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (70-7102-U100)

Dodavatel: Tonbo Biosciences

Popis: The JES5-2A5 antibody is specific for mouse IL-10. IL-10 has numerous biological activities including the ability to inhibit both the synthesis of Th1 cytokines and proliferation of T cells. In the mouse, IL-10 is produced by phagocytic cells, conventional dendritic, cells, T cells, B cells, and NK cells. The JES5-2A5 antibody is a neutralizing antibody.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (75-4714-U100)

Dodavatel: Tonbo Biosciences

Popis: The MOPC-21 immunoglobulin is useful as an isotype-matched control. The MOPC-21 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG1 antibodies.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (40-1529-U100)

Dodavatel: Tonbo Biosciences

Popis: The BNI3 antibody is specific for human CD152, commonly known as CTLA-4, a 33 to 37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (70-9919-U100)

Dodavatel: Tonbo Biosciences

Popis: The NOK-1 antibody reacts with human CD178 (Fas ligand) in both membrane bound and soluble forms. Fas ligand is a 40 kDa transmembrane glycoprotein, a member of the TNF family, and is expressed by activated T and NK cells, neutrophils, and monocytes. Interactions between CD178 (Fas ligand) and CD95 (Fas) induce a program of apoptosis and play a key role in immune regulation and homeostasis. The extracellular domain of human CD178 can be cleaved from the surface by matrix metalloproteinases (MMPs) resulting in a 26 kDa soluble protein.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (70-4714-U100)

Dodavatel: Tonbo Biosciences

Popis: The MOPC-21 immunoglobulin is useful as an isotype-matched control. The MOPC-21 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG1 antibodies.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (70-4724-U100)

Dodavatel: Tonbo Biosciences

Popis: The C1.18.4 immunoglobulin is useful as an isotype-matched control. The C.1.18.4 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2a antibodies.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (35-0021-U100)

Dodavatel: Tonbo Biosciences

Popis: The RM2-5 antibody reacts with mouse CD2, an approximately 50 kDa glycoprotein, and a member of the Ig superfamily. CD2, also known as LFA-2, is a receptor for CD48 in the mouse and is expressed on the cell surface of all mouse lymphocytes. CD2 mediates adhesion between cells and is involved in T cell activation.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (67-4724-U100)

Dodavatel: Tonbo Biosciences

Popis: The C1.18.4 immunoglobulin is useful as an isotype-matched control. The C.1.18.4 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2a antibodies.

Měrná jednotka: 1 * 100 µG

Akce