Hledali jste: odc1

Katalogové číslo: (BOSSBS-2400R-A647)

Dodavatel: Bioss

Popis: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-1309R-A647)

Dodavatel: Bioss

Popis: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2400R-A680)

Dodavatel: Bioss

Popis: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilisation of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-8998R-FITC)

Dodavatel: Bioss

Popis: The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation (1). Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins (1). ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors (1). Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis (2). ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle; however, only ORC2 remains stably bound to chromatin (3,4). ORC4 and ORC6 are also expressed constantly throughout the cell cycle (5,6). ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble (7,8). The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells (8).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI138409)

Dodavatel: US Biological

Popis: Anti-SDC1 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: 13H368]

Měrná jednotka: 1 * 100 Tests

Akce

Katalogové číslo: (USBIS9111-30F)

Dodavatel: US Biological

Popis: Anti-SDC1 Mouse Monoclonal Antibody (FITC (Fluorescein)) [clone: 6A372]

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BOSSBS-8998R-A350)

Dodavatel: Bioss

Popis: The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation (1). Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins (1). ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors (1). Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis (2). ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle; however, only ORC2 remains stably bound to chromatin (3,4). ORC4 and ORC6 are also expressed constantly throughout the cell cycle (5,6). ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble (7,8). The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells (8).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-1309R-A555)

Dodavatel: Bioss

Popis: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2400R-A488)

Dodavatel: Bioss

Popis: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (ABCAAB108290-100)

Dodavatel: Abcam

Popis: Anti-CDKA1 / DOC1 Rabbit Monoclonal Antibody [clone: R76]

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-15371R-A350)

Dodavatel: Bioss

Popis: Atypical chemokine receptor that controls chemokine levels and localisation via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalising receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalisation and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI030837-PE)

Dodavatel: US Biological

Popis: Anti-SDC1 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: 531CT15.4.1]

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (ABCAAB235369-100)

Dodavatel: Abcam

Popis: Anti-ZDHHC4/DC1 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (135-1873)

Dodavatel: ERLAB CAPTAIRE

Popis: Prefilter for column 1PC1

Měrná jednotka: 1 * 1 KS

Akce

Katalogové číslo: (USBIS9111-30E)

Dodavatel: US Biological

Popis: Anti-SDC1 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: 6A372]

Měrná jednotka: 1 * 100 Tests

Akce

Katalogové číslo: (BOSSBS-4897R-A750)

Dodavatel: Bioss

Popis: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

Měrná jednotka: 1 * 100 µl

Akce