Hledali jste: mic10

Katalogové číslo: (USBI033516-BIOTIN)

Dodavatel: US Biological

Popis: Anti-CD46 Rabbit Polyclonal Antibody (Biotin)

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (PRSI16-644)

Dodavatel: ProSci Inc.

Popis: Anti-CD46 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 50 µl

New Product Akce

Katalogové číslo: (PRSI96-123)

Dodavatel: ProSci Inc.

Popis: Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (PRSI91-297)

Dodavatel: ProSci Inc.

Popis: CD46 is a type I membrane protein containing four Sushi domains. CD46 is expressed by all cells except erythrocytes. CD46 has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. CD46 acts as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria.

Měrná jednotka: 1 * 50 µG

Akce