Hledali jste: lad1

Katalogové číslo: (PRSI4841)

Dodavatel: ProSci Inc.

Popis: Aak1 Antibody: AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxphi) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesting that Aak1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its recycling back to the plasma membrane.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (ABNOPAB25323)

Dodavatel: Abnova

Popis: Rabbit polyclonal antibody raised against synthetic phosphopeptide of ADD1.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (ORIGTA325207)

Dodavatel: OriGene

Popis: Anti-ADD1 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-9527R-A555)

Dodavatel: Bioss

Popis: 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-9527R-A647)

Dodavatel: Bioss

Popis: 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-9527R-A488)

Dodavatel: Bioss

Popis: 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-4559R-HRP)

Dodavatel: Bioss

Popis: Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta and gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-Actin junction of the membrane skeleton. The cortical Actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical Actin network organization. Adducin alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin alpha and Adducin gamma is ubiquitous in contrast to the restricted expression of Adducin beta . Adducin beta is expressed at high levels in brain and hematopoietic tissues, such as bone marrow in humans and spleen in mice.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI131759)

Dodavatel: US Biological

Popis: Anti-PRDX6 Mouse Monoclonal Antibody [clone: 3A10-2A11]

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (USBI130057)

Dodavatel: US Biological

Popis: Anti-MYL4 Mouse Monoclonal Antibody [clone: 1A11-C8]

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (USBIM4700-11L)

Dodavatel: US Biological

Popis: Anti-Mucin 1 Mouse Monoclonal Antibody [clone: VU-11D1]

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (USBI126608)

Dodavatel: US Biological

Popis: Anti-FAM65B Mouse Monoclonal Antibody [clone: 2F6-1A11]

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (BOSSBS-7954R-HRP)

Dodavatel: Bioss

Popis: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.Involvement in disease:Defects in ALAD are the cause of acute hepatic porphyria (AHP). AHP is a form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. AHP is characterized by attacks of gastrointestinal disturbances, abdominal colic, paralysis, and peripheral neuropathy. Most attacks are precipitated by drugs, alcohol, caloric deprivation, infections, or endocrine factors.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-7954R-A750)

Dodavatel: Bioss

Popis: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.Involvement in disease:Defects in ALAD are the cause of acute hepatic porphyria (AHP). AHP is a form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. AHP is characterized by attacks of gastrointestinal disturbances, abdominal colic, paralysis, and peripheral neuropathy. Most attacks are precipitated by drugs, alcohol, caloric deprivation, infections, or endocrine factors.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-9532R-A488)

Dodavatel: Bioss

Popis: AKD1 is a 1,911 amino acid coiled-coil protein belonging to the adenylate kinase family. AKD1 exists as six alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 6q21. Chromosome 6 makes up nearly 6% of the human genome and contains 170 million base pairs, which encode 1,200 genes. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. A bipolar disorder susceptibility locus is also linked to the q arm of chromosome 6. The PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins are located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-1507R-FITC)

Dodavatel: Bioss

Popis: AAK1 phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). It may play a role in regulating aspects of clathrin-mediated endocytosis. [SUBCELLULAR LOCATION] Membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Membrane, clathrin-coated pit (By similarity). Note=Active when found in clathrin-coated pits at the plasma membrane (By similarity).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI126843)

Dodavatel: US Biological

Popis: Anti-ANO10 Mouse Monoclonal Antibody [clone: 2B12-1A11]

Měrná jednotka: 1 * 100 µG

Akce