Hledali jste: exist

Katalogové číslo: (BOSSBS-9546R-A647)

Dodavatel: Bioss

Popis: FIBCD1 is a 461 amino acid single-pass membrane protein that contains one fibrinogen C-terminal domain and exists as multiple alternatively spliced isoforms. The gene encoding FIBCD1 maps to human chromosome 9, which contains 145 million base pairs, comprises 4% of the human genome and encodes nearly 900 genes.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2709R-CY5.5)

Dodavatel: Bioss

Popis: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-15420R-CY3)

Dodavatel: Bioss

Popis: HBS1L is a 684 amino acid protein that belongs to the GTP-binding elongation factor family and exists as multiple alternatively spliced isoforms. Expressed in kidney, brain, heart, placenta, liver, muscle and pancreas, HSB1L is thought to play a role in controlling fetal hemoglobin levels, specifically influencing platelet, monocyte and erythrocyte hemoglobin content. The gene encoding HBS1L maps to a locus on human chromosome 6 that is associated with sickle cell anemia and _-thalassemia, suggesting a role for HBS1L in the pathogenesis of blood disorders.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-9473R-HRP)

Dodavatel: Bioss

Popis: The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-9473R-FITC)

Dodavatel: Bioss

Popis: The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-13196R-CY5)

Dodavatel: Bioss

Popis: This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008].

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12950R)

Dodavatel: Bioss

Popis: TORC3 is a 619 amino acid protein that localizes to both the cytoplasm and the nucleus and belongs to the TORC family. Expressed in lung tissue and B and T lymphocytes, as well as in colon, brain, ovary, kidney, prostate, colon and heart, TORC3 functions as a transcriptional coactivator for CREB-1, thereby regulating the expression of CREB-activated genes, and is also thought to activate the SIK/TORC signaling pathway. TORC3 exists as multiple alternatively spliced isoforms and, in addition to its role in transcriptional activation, is thought to induce mitochondrial biogenesis, specifically in muscle cells.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12267R)

Dodavatel: Bioss

Popis: LCRG1 is a 697 amino acid protein that may be involved in spermatogenesis. LCRG1 interacts with gametogenetin, a protein primarily expressed in testis and ovary. Localized in the cytoplasm, LCRG associates with vesicular structures. LCRG1 is expressed in brain, placenta, lung, liver and kidney, with highest levels found in heart, pancreas and skeletal muscle. LCRG1 is strongly down-regulated in 40% of primary laryngeal carcinoma and in 6 of 10 various cancer cell lines. Phosphorylated on Serine 360, LCRG1 exists as three isoforms produced by alternative splicing events.

Měrná jednotka: 1 * 100 µl

Akce

Dodavatel: Biotium

Popis: This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin's lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Katalogové číslo: (BOSSBS-8319R)

Dodavatel: Bioss

Popis: LHPP, also known as HDHD2B, is a 270 amino acid protein that exists as a homodimer and is a member of the HAD-like hydrolase superfamily. Expressed in liver, kidney and moderately in brain, LHPP is encoded by a gene located on 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12438R-A647)

Dodavatel: Bioss

Popis: LRRFIP2 is a 721 amino acid protein that belongs to the LRRFIP family. Ubiquitously expressed, LRRFIP2 acts as an activator of the Wnt signaling pathway and as a positive regulator of NFâ…¹B activity. LRRFIP2 may be involved in regulating cytokine production in macrophages, suggesting a functional role in the TLR4-mediated inflammatory response. Three isoforms of LRRFIP2 exists due to alternative splicing events.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12438R-A555)

Dodavatel: Bioss

Popis: LRRFIP2 is a 721 amino acid protein that belongs to the LRRFIP family. Ubiquitously expressed, LRRFIP2 acts as an activator of the Wnt signaling pathway and as a positive regulator of NFâ…¹B activity. LRRFIP2 may be involved in regulating cytokine production in macrophages, suggesting a functional role in the TLR4-mediated inflammatory response. Three isoforms of LRRFIP2 exists due to alternative splicing events.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12438R-HRP)

Dodavatel: Bioss

Popis: LRRFIP2 is a 721 amino acid protein that belongs to the LRRFIP family. Ubiquitously expressed, LRRFIP2 acts as an activator of the Wnt signaling pathway and as a positive regulator of NFâ…¹B activity. LRRFIP2 may be involved in regulating cytokine production in macrophages, suggesting a functional role in the TLR4-mediated inflammatory response. Three isoforms of LRRFIP2 exists due to alternative splicing events.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2709R-HRP)

Dodavatel: Bioss

Popis: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-12543R-CY7)

Dodavatel: Bioss

Popis: ATF-6 is a member of the basic-leucine zipper family of transcription factors. Endoplasmic reticulum stress causes cleavage of transmembrane ATF-6 and transclocation of active ATF-6 to the nucleus. Soluble ATF-6 can exist as either an ATF-6beta homodimer or an ATF-6Alpha/beta heterodimer. Binding of the ATF-6beta homodimer or ATF-6Alpha/beta heterodimer to the nuclear transcription factor Y C (NF-YC) induces ER chaperone transcription.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-15453R)

Dodavatel: Bioss

Popis: HEMK2 is a 214 amino acid protein that belongs to the methyltransferase superfamily and exists as multiple alternatively spliced isoforms. The gene encoding HEMK2 maps to human chromosome 21, which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).

Měrná jednotka: 1 * 100 µl

Akce