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Katalogové číslo: (PRSI4513)

Dodavatel: ProSci Inc.

Popis: LGI4 Antibody: The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSI4533)

Dodavatel: ProSci Inc.

Popis: LGI2 Antibody: The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSI5433)

Dodavatel: ProSci Inc.

Popis: CENPO Antibody: Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSI4511)

Dodavatel: ProSci Inc.

Popis: LGI4 Antibody: The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSI4493)

Dodavatel: ProSci Inc.

Popis: LGI3 Antibody: The leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE. LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Abeta) peptide and accumulated on neuronal plasma membranes of aged monkey brains and co-localized with Abeta.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (PRSI4491)

Dodavatel: ProSci Inc.

Popis: LGI2 Antibody: The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE.

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (EDVO334)

Dodavatel: EDVOTEK

Popis: In DNA fingerprinting, variable number tandem repeats (VNTR) are used to identify individuals. Using this kit, students type themselves at the D1S80 locus on chromosome 1. This region contains between 14 and 40 copies of a 16 base pair repeat.

Měrná jednotka: 1 * 1 KIT

Akce

Dodavatel: Thermo Scientific

Popis: A single crystal is a material in which the crystal lattice of the entire sample is continuous and unbroken to the edges of the sample, with no grain boundaries.

Bezpečnostní list Certifikáty

Katalogové číslo: (ENZOADILYTHM100F)

Dodavatel: ENZO LIFE SCIENCES

Popis: Microsomes are a rich source of heme-containing metabolic enzymes, including heme-oxygenases and cytochrome P450 (CYP) enzymes, and are commonly used in the study of xenobiotic drug metabolism. Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells.

Měrná jednotka: 1 * 200 µG

New Product Akce

Dodavatel: Thermo Scientific

Popis: Sapphire spheres, Grade/stupeň/jakost: 25, Ø: 1,50 mm

Bezpečnostní list

Katalogové číslo: (ENZOADILYTRB100F)

Dodavatel: ENZO LIFE SCIENCES

Popis: Rat brain tissue extract

Měrná jednotka: 1 * 200 µG

New Product Akce

Katalogové číslo: (ICNA092850145)

Dodavatel: MP Biomedicals

Popis: Chicken embryo extract prepared from nine to 12 day old eggs.

Měrná jednotka: 1 * 20 mL

Bezpečnostní list Akce