Hledali jste: ackr2

Katalogové číslo: (BOSSBS-2775R-CY3)

Dodavatel: Bioss

Popis: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2775R-CY5)

Dodavatel: Bioss

Popis: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-2775R-A555)

Dodavatel: Bioss

Popis: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (ABNOPAB24976)

Dodavatel: Abnova

Popis: Rabbit polyclonal antibody raised against synthetic peptide of CCBP2.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (PRSI27-311)

Dodavatel: ProSci Inc.

Popis: CCBP2 is a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown.This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

Měrná jednotka: 1 * 50 µG

Akce

Katalogové číslo: (ANTIA325111-100)

Dodavatel: ANTIBODIES.COM

Popis: [EN]NANODISC HUMAN ACKR2 PROTEIN 1 * 100 µG

Měrná jednotka: 1 * 100 µG

New Product Akce

Katalogové číslo: (BSBTA05491-2)

Dodavatel: Boster Bio

Popis: ANTI-D6/ACKR2 PICOBAND+TRADE ANTIBODY 1 * 100 µG

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (ANTIA325111-50)

Dodavatel: ANTIBODIES.COM

Popis: [EN]NANODISC HUMAN ACKR2 PROTEIN 1 * 50 µG

Měrná jednotka: 1 * 50 µG

New Product Akce

Katalogové číslo: (ANTIA325111-10)

Dodavatel: ANTIBODIES.COM

Popis: [EN]NANODISC HUMAN ACKR2 PROTEIN 1 * 10 µG

Měrná jednotka: 1 * 10 µG

New Product Akce

Katalogové číslo: (ANTIA99834-100)

Dodavatel: ANTIBODIES.COM

Popis: Rabbit polyclonal antibody to CCBP2 for WB, IF and ELISA with samples derived from human.

Měrná jednotka: 1 * 100 µG

New Product Akce

Katalogové číslo: (ANTIA101186-100)

Dodavatel: ANTIBODIES.COM

Popis: Rabbit polyclonal antibody to CCBP2 for WB and ELISA with samples derived from human.

Měrná jednotka: 1 * 100 µG

New Product Akce

Katalogové číslo: (ANTIA101185-100)

Dodavatel: ANTIBODIES.COM

Popis: Rabbit polyclonal antibody to CCBP2 for IF and ELISA with samples derived from human.

Měrná jednotka: 1 * 100 µG

New Product Akce

Katalogové číslo: (AVIVARP30776_P050)

Dodavatel: Aviva Systems Biology

Popis: Anti-CCBP2 Rabbit Polyclonal Antibody

Měrná jednotka: 1 * 50 µG

Akce