Hledali jste: Ethyl-2-bromoisovalerate

Katalogové číslo: (BOSSBS-2277R-A350)

Dodavatel: Bioss

Popis: This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (USBI037175-HRP)

Dodavatel: US Biological

Popis: Anti-JAK1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (USBI037175-FITC)

Dodavatel: US Biological

Popis: Anti-JAK1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (BOSSBS-1227R-A680)

Dodavatel: Bioss

Popis: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (ABCAAB321622-100UL)

Dodavatel: Abcam

Popis: Anti-PAK1+PAK2+PAK3 (phospho S154) Rabbit Monoclonal Antibody [clone: EP656Y] (Alexa Fluor® 750)

Měrná jednotka: 1 * 100 µl

New Product Akce

Katalogové číslo: (BOSSBS-2277R-A488)

Dodavatel: Bioss

Popis: This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-7594R-FITC)

Dodavatel: Bioss

Popis: Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008].

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-3238R-A350)

Dodavatel: Bioss

Popis: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-3238R-A488)

Dodavatel: Bioss

Popis: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-3238R-A555)

Dodavatel: Bioss

Popis: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-3238R-FITC)

Dodavatel: Bioss

Popis: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (ABCAAB319511-100UL)

Dodavatel: Abcam

Popis: Anti-PAK1 Rabbit Monoclonal Antibody [clone: EPR20048] (Alexa Fluor® 488)

Měrná jednotka: 1 * 100 µl

New Product Akce

Katalogové číslo: (USBIP2488-01P-AP)

Dodavatel: US Biological

Popis: Anti-PAK1 Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (USBI037175-PE)

Dodavatel: US Biological

Popis: Anti-JAK1 Rabbit Polyclonal Antibody (PE (Phycoerythrin))

Měrná jednotka: 1 * 200 µl

Akce

Katalogové číslo: (USBIB0055-10D-FITC)

Dodavatel: US Biological

Popis: Anti-BAK1 Rabbit Polyclonal Antibody (FITC (Fluorescein))

Měrná jednotka: 1 * 200 µl

Akce

Dodavatel: Abcam

Popis: Anti-PAK1 Rabbit Monoclonal Antibody [clone: EPR20048]