Hledali jste: Staurosporine

Katalogové číslo: (BOSSBS-0738R-A680)

Dodavatel: Bioss

Popis: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BOSSBS-0738R-HRP)

Dodavatel: Bioss

Popis: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (BSENS-077-100)

Dodavatel: Biosensis

Popis: Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects neurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1).

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (00025.)

Dodavatel: Biotium

Popis: Staurosporine is a potent apoptosis inducer.

Měrná jednotka: 1 * 100 µG

Akce

Dodavatel: MP Biomedicals

Popis: Staurosporine is provided in a lyophilised form. It may be reconstituted by dissolving the lyophilised reagent in DMSO (5 mg/ml - clear, colourless solution), DMF, ethyl acetate (5 mg/ml - clear colourless solution) or methanol. Stock solutions should be further diluted with aqueous buffers just prior to use. Stability depends upon the quality of solvent used. The compound should be stored at −20 °C in the dark.

Katalogové číslo: (AATB80050)

Dodavatel: AAT BIOQUEST

Popis: Staurosporine is widely used as a positive control for inducing apoptosis.

Měrná jednotka: 1 * 100 µl

Akce

Katalogové číslo: (J62837.MA)

Dodavatel: Thermo Fisher Scientific

Popis: Staurosporine ≥99%

Měrná jednotka: 1 * 10 mg

Bezpečnostní list Certifikáty Akce

Katalogové číslo: (37095-10MG)

Dodavatel: Merck

Popis: Organic Standard, Staurosporine

Měrná jednotka: 1 * 10 mg

Akce

Katalogové číslo: (HONCR1061-10MG)

Dodavatel: Honeywell Chemicals

Popis: Organic Standard, Staurosporine, Typ balení: Glass Bottle

Měrná jednotka: 1 * 10 mg

Akce

Dodavatel: ENZO LIFE SCIENCES

Popis: Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.

New Product

Katalogové číslo: (PRSI55-786)

Dodavatel: ProSci Inc.

Popis: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Měrná jednotka: 1 * 400 µl

New Product Akce

Katalogové číslo: (ABCAAB146588-100)

Dodavatel: Abcam

Popis: STAUROSPORINE (DMSO SOLUTION) 1 * 100 µG

Měrná jednotka: 1 * 100 µG

Akce

Katalogové číslo: (CAYM81590-1)

Dodavatel: Cayman Chemical

Popis: STAUROSPORINE 1 * 1 mg

Měrná jednotka: 1 * 1 mg

Akce

Katalogové číslo: (ABCAAB120056-100)

Dodavatel: Abcam

Popis: STAUROSPORINE 1 * 100 µG

Měrná jednotka: 1 * 100 µG

Bezpečnostní list Akce

Katalogové číslo: (CAYM81590-500)

Dodavatel: Cayman Chemical

Popis: STAUROSPORINE 1 * 500 µG

Měrná jednotka: 1 * 500 µG

Akce

Katalogové číslo: (ABCAAB136806-2)

Dodavatel: Abcam

Popis: HELA APOPTOSIS LYSATE SET: STAUROSPORINE 1 * 2 JV

Měrná jednotka: 1 * 2 JV

Akce