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Image Unavailable-BOSSBS-3442R-A488

Anti-TSC2 SER939 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Popis: Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.
Katalogové číslo: BOSSBS-3442R-A488
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-3443R-A350

Anti-TSC2 TYR1571 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Popis: Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.
Katalogové číslo: BOSSBS-3443R-A350
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-3441R-FITC

Anti-SER1387 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Popis: Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.
Katalogové číslo: BOSSBS-3441R-FITC
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BNC400835-500

Anti-KRT18 Mouse Monoclonal Antibody (CF640R) [clone: KRT18/835]

Popis: This MAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It is reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
Katalogové číslo: BNC400835-500
Měrná jednotka: 1 * 500 µl
Dodavatel: Biotium
Image Unavailable-BOSSBS-11841R-CY3

Anti-FNBP1L Rabbit Polyclonal Antibody (Cy3®)

Popis: TOCA-1 is a 605 amino acid protein that localizes to the cytoplasm and the cytoskeleton, as well as to cytoplasmic vesicles and the cell membrane, and contains one FCH domain, one REM repeat and one SH3 domain. Existing as multiple alternatively spliced isoforms, TOCA-1 interacts with CDC42 and is required for the coordination of membrane tubulation with Actin cytoskeletal reorganization during endocytosis. Additionally, TOCA-1 is involved in membrane invagination, tubule formation and Actin polymerization. The gene encoding TOCA-1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
Katalogové číslo: BOSSBS-11841R-CY3
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-12324R-CY3

Anti-PTCHD2 Rabbit Polyclonal Antibody (Cy3®)

Popis: PTCHD2 is a 1,392 amino acid multi-pass membrane protein that contains one SSD (sterol-sensing) domain and belongs to the patched family. Expressed in retina, brain and testis, PTCHD2 localizes to endoplasmic reticulum and colocalizes with cholesterol. PTCHD2 overexpression leads to increased cholesterol levels, suggesting that PTCHD2 may play a role in cholesterol homeostasis. PTCHD2 is further hypothesized to act as a link between thyroid hormone and cholesterol metabolism. Existing as two alternatively spliced isoforms, PTCHD2 is thought to assist in the release of lipid-anchored secreted proteins and is encoded by a gene that maps to human chromosome 1p36.22.
Katalogové číslo: BOSSBS-12324R-CY3
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-15436R-HRP

Anti-HEAB Rabbit Polyclonal Antibody (HRP)

Popis: HEAB is a 425 amino acid nuclear protein that belongs to the Clp1 family. Utilising magnesium, manganese or nickel as cofactors, HEAB participates in the phosphorylation of the 5'-hydroxyl groups of double- and single- stranded RNA and DNA. HEAB is a member of the tRNA splicing endonuclease complex, in conjunction with TSEN2, TSEN15, TSEN34 and TSEN54, and is also a member of the pre-mRNA cleavage complex II. The gene encoding HEAB maps to human chromosome 11q12.1 and mouse chromosome 2 D; mutations to this gene may lead to a reduced pre-mRNA cleavage activity. HEAB exists as two isoforms due to alternative splicing events.
Katalogové číslo: BOSSBS-15436R-HRP
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-5571R-CY5

Anti-PIK3R1 Rabbit Polyclonal Antibody (Cy5®)

Popis: The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Katalogové číslo: BOSSBS-5571R-CY5
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-15436R-A555

Anti-HEAB Rabbit Polyclonal Antibody (ALEXA FLUOR® 555)

Popis: HEAB is a 425 amino acid nuclear protein that belongs to the Clp1 family. Utilising magnesium, manganese or nickel as cofactors, HEAB participates in the phosphorylation of the 5'-hydroxyl groups of double- and single- stranded RNA and DNA. HEAB is a member of the tRNA splicing endonuclease complex, in conjunction with TSEN2, TSEN15, TSEN34 and TSEN54, and is also a member of the pre-mRNA cleavage complex II. The gene encoding HEAB maps to human chromosome 11q12.1 and mouse chromosome 2 D; mutations to this gene may lead to a reduced pre-mRNA cleavage activity. HEAB exists as two isoforms due to alternative splicing events.
Katalogové číslo: BOSSBS-15436R-A555
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-15436R-A350

Anti-HEAB Rabbit Polyclonal Antibody (ALEXA FLUOR® 350)

Popis: HEAB is a 425 amino acid nuclear protein that belongs to the Clp1 family. Utilising magnesium, manganese or nickel as cofactors, HEAB participates in the phosphorylation of the 5'-hydroxyl groups of double- and single- stranded RNA and DNA. HEAB is a member of the tRNA splicing endonuclease complex, in conjunction with TSEN2, TSEN15, TSEN34 and TSEN54, and is also a member of the pre-mRNA cleavage complex II. The gene encoding HEAB maps to human chromosome 11q12.1 and mouse chromosome 2 D; mutations to this gene may lead to a reduced pre-mRNA cleavage activity. HEAB exists as two isoforms due to alternative splicing events.
Katalogové číslo: BOSSBS-15436R-A350
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-15436R-A488

Anti-HEAB Rabbit Polyclonal Antibody (ALEXA FLUOR® 488)

Popis: HEAB is a 425 amino acid nuclear protein that belongs to the Clp1 family. Utilising magnesium, manganese or nickel as cofactors, HEAB participates in the phosphorylation of the 5'-hydroxyl groups of double- and single- stranded RNA and DNA. HEAB is a member of the tRNA splicing endonuclease complex, in conjunction with TSEN2, TSEN15, TSEN34 and TSEN54, and is also a member of the pre-mRNA cleavage complex II. The gene encoding HEAB maps to human chromosome 11q12.1 and mouse chromosome 2 D; mutations to this gene may lead to a reduced pre-mRNA cleavage activity. HEAB exists as two isoforms due to alternative splicing events.
Katalogové číslo: BOSSBS-15436R-A488
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-13697R-A350

Anti-TMEM115 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Popis: Transmembrane proteins contain transmembrane domains that are usually characterized by alpha-helical structures. Transmembrane proteins exist as thermodynamically stable hetero- and homodimers that interact with the lipid bilayer and are involved in both material exchange and communication between the cell and the environment. PL6 is a 351 amino acid multi-pass membrane protein that is highly expressed in kidney and skeletal muscle with lower levels of expression detected in liver, placenta, prancreas, lung, heart and brain. PL6 contains one phosphoserine residue and several transmembrane domains, suggesting that it may participate in protein exchange and signaling events between cells.
Katalogové číslo: BOSSBS-13697R-A350
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-13697R-A555

Anti-TMEM115 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Popis: Transmembrane proteins contain transmembrane domains that are usually characterized by alpha-helical structures. Transmembrane proteins exist as thermodynamically stable hetero- and homodimers that interact with the lipid bilayer and are involved in both material exchange and communication between the cell and the environment. PL6 is a 351 amino acid multi-pass membrane protein that is highly expressed in kidney and skeletal muscle with lower levels of expression detected in liver, placenta, prancreas, lung, heart and brain. PL6 contains one phosphoserine residue and several transmembrane domains, suggesting that it may participate in protein exchange and signaling events between cells.
Katalogové číslo: BOSSBS-13697R-A555
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-67-9459-T100

Anti-CD45 Mouse Monoclonal Antibody (PerCP) [clone: 2D1]

Popis: The 2D1 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, and CD45RO.
Katalogové číslo: 67-9459-T100
Měrná jednotka: 1 * 100 Tests
Dodavatel: Tonbo Biosciences
Image Unavailable-BOSSBS-12366R-HRP

Anti-SUMF1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Popis: SUMF1 is a 374 amino acid alternatively spliced protein that localizes to the lumen of the endoplasmic reticulum and belongs to the sulfatase-modifying factor family. Expressed ubiquitously with highest expression in liver, kidney and pancreas, SUMF1 exists as either a monomer, a homodimer or a heterodimer (with SUMF2) and functions to oxidize sulfatase cysteine residues to an active FGIy residue, thereby playing an important role in sulfatase activity. Defects in the gene encoding SUMF1 are the cause of multiple sulfatase deficiency (MSD), a heterogeneous disorder characterized by metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.
Katalogové číslo: BOSSBS-12366R-HRP
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-11525R-HRP

Anti-MICAL1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Popis: MICAL1 is a 1,067 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one LIM zinc-binding domain and one calponin-homology domain. Expressed in kidney, thymus, spleen, lung and testis, MICAL1 interacts with the SH3 domain of Cas-L and, via this interaction, is thought to function as a cytoskeletal regulator that connects Cas-L to intermediate filaments. MICAL1 also interacts with Rab 1B, plexin-A3 and Vimentin, further regulating cytoskeletal events and possibly playing a role in axonal repulsion. Three isoforms of MICAL1 exist due to alternative splicing events.
Katalogové číslo: BOSSBS-11525R-HRP
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
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