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Image Unavailable-BOSSBS-15482R-A750

Anti-hHR23b Rabbit Polyclonal Antibody (ALEXA FLUOR® 750)

Katalogové číslo: (BOSSBS-15482R-A750)
Dodavatel: Bioss
Popis: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Měrná jednotka: 1 * 100 µl
Image Unavailable-BOSSBS-15482R-CY5

Anti-hHR23b Rabbit Polyclonal Antibody (Cy5)

Katalogové číslo: (BOSSBS-15482R-CY5)
Dodavatel: Bioss
Popis: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Měrná jednotka: 1 * 100 µl

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Image Unavailable-BOSSBS-6634R-A750

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Katalogové číslo: (BOSSBS-6634R-A750)
Dodavatel: Bioss
Popis: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Měrná jednotka: 1 * 100 µl
Image Unavailable-SPCMT1708-100GMBL

Tyloxapol USP

Dodavatel: Spectrum Chemical
Popis: Tyloxapol USP

Image Unavailable-SPCMMA115-2.5KG

Magnesium hydroxide ≥95%, powder USP

Katalogové číslo: (SPCMMA115-2.5KG)
Dodavatel: Spectrum Chemical
Popis: Magnesium Hydroxide, Powder, USP is used to treat symptoms caused by too much stomach acid such as heartburn, upset stomach, or indigestion. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Měrná jednotka: 1 * 2,5 kg
Image Unavailable-SPCMS1118-2.5KG

Alginát sodný NF

Dodavatel: Spectrum Chemical
Popis: Sodium Alginate, NF is a gum that has no discernible flavor and is used in the food and pharmaceutical industries as an emulsifier and to increase viscosity. All Spectrum Chemical manufactured NF grade products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCMA1167-2.5KG

Chlorid amonný ≥99.0%, granular FCC

Katalogové číslo: (SPCMA1167-2.5KG)
Dodavatel: Spectrum Chemical
Popis: Ammonium Chloride, Granular, FCC is an ingredient in nutritive media for yeasts and many microorganisms. Spectrum Chemical offers over 300 Food Grade (FCC) chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities
Měrná jednotka: 1 * 2,5 kg
Image Unavailable-SPCMBE156-1KGBL

Dibenzoylperoxid 75%, hydrous ≥75% USP

Dodavatel: Spectrum Chemical
Popis: Hydrous Benzoyl Peroxide, 75 Percent, USP is used to treat mild to moderate acne. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCMFE109-2.5KGPL

Ferrous gluconate dihydrate 97,0 USP

Dodavatel: Spectrum Chemical
Popis: Ferrous Gluconate, USP is used to treat iron deficiency anemia. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCMA1009-4LTPV

Acetic acid glacial_AcOH FCC

Katalogové číslo: (SPCMA1009-4LTPV)
Dodavatel: Spectrum Chemical
Popis: Acetic Acid, Glacial, FCC is used in the pickling of vegetables and other foods. Spectrum Chemical offers over 300 Food Grade (FCC) chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Měrná jednotka: 1 * 4 L
Image Unavailable-SPCMA1330-12KG

Antimony(III) oxide, Reagent Grade

Dodavatel: Spectrum Chemical
Popis: Antimony Trioxide, Reagent is an inorganic compound and crucial as a commercial compound of antimony. It is an opacifying agent for glasses, ceramics and enamels. The Reagent grade denotes that this chemical is the highest quality commercially available and that the American Chemical Society has not officially set any specifications for this material. Spectrum Chemical manufactured Reagent grade products meet the toughest regulatory standards for quality and purity.

Image Unavailable-SPCMA1293-4LTPV

Ammonia solution 27 - 30% FCC

Dodavatel: Spectrum Chemical
Popis: Ammonia Solution, FCC is a solution of Ammonia in water. It has many uses, but in food production it is used primarily as a leavening agent. Spectrum Chemical offers over 300 Food Grade (FCC) chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCMP1571-100GM

Pepsin

Dodavatel: Spectrum Chemical
Popis: Commonly used in biochemistry.

New Product

Image Unavailable-SPCMP1216-500GM

Polyvinylpyrrolidone, M.W. ∼ 40,000 K-30 FCC

Katalogové číslo: (SPCMP1216-500GM)
Dodavatel: Spectrum Chemical
Popis: Polyvinylpyrrolidone K-30, FCC is used as an iodine antiseptic. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Měrná jednotka: 1 * 500 g
Image Unavailable-SPCMV1031-500MLGL

Vegetable oil brominated FCC

Dodavatel: Spectrum Chemical
Popis: Brominated Vegetable Oil, FCC, also known as BVO, is a mix of plant-derived triglycerides and is used to help emulsify citrus flavored drinks. Spectrum Chemical offers over 300 Food Grade (FCC) chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCMM1193-4LTGL

Mineral oil light FCC, low viscosity

Dodavatel: Spectrum Chemical
Popis: Mineral Oil, Low Viscosity, FCC - The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Cena na vyžádání
Omezené množství produktu na skladě. Zboží může být k dispozici v jiném skladě poblíž vašeho sídla. Přesvědčte se, že jste přihlášení na stránky, abyste mohli vidět dostupné položky na skladě. Pokud je stále zobrazeno call a potřebujete asistenci, volejte na číslo 321 570 321.
Omezené množství produktu na skladě. Zboží může být k dispozici v jiném skladě poblíž vašeho sídla. Přesvědčte se, že jste přihlášení na stránky, abyste mohli vidět dostupné položky na skladě. Pokud je stále zobrazeno call a potřebujete asistenci, volejte na číslo 321 570 321.
Daná chemikálie je regulována dle platné legislativy a bude vyžadováno vyplnění formuláře. Jeho včasným vyplněním uspíšíte dodání produktu.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Tento produkt je zablokován vaší organizací. Kontaktujte své nákupní oddělení pro více informací.
Původní produkt již není k dispozici. Zobrazen je náhradní produkt.
Tento produkt již není k dispozici. Podobné produkty můžete vyhledat pomocí VWR katalogových čísel nebo čísel dodavatele uvedených výše. Pokud potřebujete další asistenci, zavolejte na telefonní číslo zákaznického servisu VWR 321 570 321.
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