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Image Unavailable-BOSSBS-11043R-A488

Anti-BEST4 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Popis: Bestrophin-4 is a 473 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels. Bestrophin-4 acts as a calcium-sensitive chloride channel located in the cell membrane. It is believed that Bestrophin-4 also acts as a channel for other physiologically significant anions, such as bicarbonate. Bestrophin-4 is predominantly expressed in the colon, but can be found at low levels in testis, placenta, trachea, spinal chord, lung and retina.
Katalogové číslo: BOSSBS-11043R-A488
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-11043R-A647

Anti-BEST4 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Popis: Bestrophin-4 is a 473 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels. Bestrophin-4 acts as a calcium-sensitive chloride channel located in the cell membrane. It is believed that Bestrophin-4 also acts as a channel for other physiologically significant anions, such as bicarbonate. Bestrophin-4 is predominantly expressed in the colon, but can be found at low levels in testis, placenta, trachea, spinal chord, lung and retina.
Katalogové číslo: BOSSBS-11043R-A647
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-11043R-FITC

Anti-BEST4 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Popis: Bestrophin-4 is a 473 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels. Bestrophin-4 acts as a calcium-sensitive chloride channel located in the cell membrane. It is believed that Bestrophin-4 also acts as a channel for other physiologically significant anions, such as bicarbonate. Bestrophin-4 is predominantly expressed in the colon, but can be found at low levels in testis, placenta, trachea, spinal chord, lung and retina.
Katalogové číslo: BOSSBS-11043R-FITC
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-0013R-A750

Anti-CYC Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Popis: Electron carrier protein. The oxidised form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Katalogové číslo: BOSSBS-0013R-A750
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-0013R-CY3

Anti-CYCS Rabbit Polyclonal Antibody (Cy3®)

Popis: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Katalogové číslo: BOSSBS-0013R-CY3
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-2733R-A680

Anti-Bcl-10 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Popis: Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Katalogové číslo: BOSSBS-2733R-A680
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Product Image-SOLUL-7206-5

TriLink® CleanCap® Cas9 mRNA (5 moU)

Popis: Cas9 mRNA expresses a version of the <em>Streptococcus pyogenes</em> SF370 Cas9 protein (CRISPR Associated Protein 9). Cas9 functions as part of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing system. In the CRISPR system, an RNA guide sequence targets the site of interest, and the Cas9 protein is employed to perform double-stranded DNA cleavage.
Katalogové číslo: SOLUL-7206-5
Měrná jednotka: 1 * 5 mg
Dodavatel: TriLink BioTechnologies

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Image Unavailable-BOSSBS-12408R-CY3

Anti-SNX10 Rabbit Polyclonal Antibody (Cy3®)

Popis: Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. SNXs are widely expressed, although the tissue distribution of each SNX mRNA varies. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNX10 (Sorting nexin-10) is a 201 amino acid protein that contains one phox domain and belongs to the SNX family. Like other members of the SNX family, SNX10 is thought to play a role in intracellular trafficking events throughout the cell.
Katalogové číslo: BOSSBS-12408R-CY3
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-12250R-CY3

Anti-SNX7 Rabbit Polyclonal Antibody (Cy3®)

Popis: Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. SNXs are widely expressed, although the tissue distribution of each SNX mRNA varies. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNXs partially associate with cellular membranes, despite their hydrophilic nature. SNX7 is unique in that it does not have a coiled coil region like some of the SNX family members. Mutations in the SNX7 gene have not been shown to cause any diseases.
Katalogové číslo: BOSSBS-12250R-CY3
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-9687R-A750

Anti-BLNK Tyr84 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Popis: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream Signalling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct Signalling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukaemia. Alternatively spliced transcript variants have been found for this gene.
Katalogové číslo: BOSSBS-9687R-A750
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-3818R-A488

Anti-GDF15 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Popis: Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues.GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.
Katalogové číslo: BOSSBS-3818R-A488
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-7613R-A350

Anti-RNF144B Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Popis: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
Katalogové číslo: BOSSBS-7613R-A350
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-11043R-A555

Anti-BEST4 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Popis: Bestrophin-4 is a 473 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels. Bestrophin-4 acts as a calcium-sensitive chloride channel located in the cell membrane. It is believed that Bestrophin-4 also acts as a channel for other physiologically significant anions, such as bicarbonate. Bestrophin-4 is predominantly expressed in the colon, but can be found at low levels in testis, placenta, trachea, spinal chord, lung and retina.
Katalogové číslo: BOSSBS-11043R-A555
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-5870R-A488

Anti-KLK6 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Popis: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Katalogové číslo: BOSSBS-5870R-A488
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-5870R-HRP

Anti-KLK6 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Popis: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Katalogové číslo: BOSSBS-5870R-HRP
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
Image Unavailable-BOSSBS-5870R-FITC

Anti-KLK6 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Popis: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Katalogové číslo: BOSSBS-5870R-FITC
Měrná jednotka: 1 * 100 µl
Dodavatel: Bioss
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